ID   CROM_NOTSL              Reviewed;         495 AA.
AC   P30842;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Omega-crystallin;
OS   Nototodarus sloanii (Wellington flying squid) (Ommastrephes sloanei).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Decapodiformes; Teuthida; Oegopsina; Ommastrephidae;
OC   Nototodarus.
OX   NCBI_TaxID=215440;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7684383; DOI=10.1016/s0021-9258(18)82144-5;
RA   Zinovieva R.D., Tomarev S.I., Piatigorsky J.;
RT   "Aldehyde dehydrogenase-derived omega-crystallins of squid and octopus.
RT   Specialization for lens expression.";
RL   J. Biol. Chem. 268:11449-11455(1993).
CC   -!- FUNCTION: Omega-crystallins are structural components of squids and
CC       octopi eye lens. Contains relatively little if any DHAL activity.
CC   -!- TISSUE SPECIFICITY: Lens.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; L06903; AAA29406.1; -; Genomic_DNA.
DR   AlphaFoldDB; P30842; -.
DR   SMR; P30842; -.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
PE   2: Evidence at transcript level;
KW   Eye lens protein.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..495
FT                   /note="Omega-crystallin"
FT                   /id="PRO_0000056602"
SQ   SEQUENCE   495 AA;  56091 MW;  C43473A2C4DF67F1 CRC64;
     MAGIPPPTRN PEIKHNKIFI NNQFVNSTSN KAYPVYNPCD NEKVCEVQEG DKSDIDKAVQ
     ACKAAFKRGT PWRRMDASRL GHLLYRLADL MERDIAYMAS LETMDTGKPY KNSYQDMVHC
     IQVLRYFAGW ADKNMGESIP VDGDFFCYTR NEPVGVCGLL IPYNYPMLMM TWKMAPALAC
     GNCMIVKPAE QTPLTALYCA SLIKEAGFPP GVVNVVPGFG KICGQYISSH QEINKVSFTG
     STEVGMLVMQ DAGKSNLKRC SMQLSGKCPL VVFEDTELDF AVQQAHEAAF QNMGQCRWSG
     SRTYVHENIY DEFVKRAVEK ATSRKTGDPY EMDTEHGPQI DEEQYKKIME FIKKGKDKGA
     QLKCGGNRHG DKGFYVEPTV FSDVTDEMKF SQEEIFGPVQ LIMKFKDMDE VIDRCNNTDY
     GMAAAIFTND INRSITFTHA MYCGTVWVNT YNHWFPQAPF GGYKKSGLYR EMGKYTLQEY
     TEVKNIVYRI PQKNS