ID   CROS1_CROSA             Reviewed;         168 AA.
AC   Q29W25;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 22.
DE   RecName: Full=Pollen allergen Cro s 1 {ECO:0000303|PubMed:26989701, ECO:0000312|EMBL:AAX93750.1};
DE   AltName: Allergen=Cro s 1 {ECO:0000303|PubMed:26989701};
DE   Flags: Precursor;
OS   Crocus sativus (Saffron).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Asparagales; Iridaceae;
OC   Crocoideae; Croceae; Crocus.
OX   NCBI_TaxID=82528 {ECO:0000312|EMBL:AAX93750.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 27-41, SUBCELLULAR
RP   LOCATION, TISSUE SPECIFICITY, AND ALLERGEN.
RC   TISSUE=Pollen {ECO:0000303|PubMed:26989701};
RX   PubMed=26989701;
RA   Varasteh A.R., Sankian M., Midoro-Horiuti T., Moghadam M., Shakeri M.T.,
RA   Brooks E.G., Goldblum R.M., Chapman M.D., Pomes A.;
RT   "Molecular cloning and expression of Cro s 1: an occupational allergen from
RT   saffron pollen (Crocus sativus).";
RL   Rep. Biochem. Mol. Biol. 1:1-8(2012).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26989701}.
CC   -!- TISSUE SPECIFICITY: Expressed in pollen. {ECO:0000269|PubMed:26989701}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE of saffron
CC       pollen-sensitized patients. Important allergen in workers of saffron
CC       industry. {ECO:0000269|PubMed:26989701}.
CC   -!- SIMILARITY: Belongs to the Ole e I family. {ECO:0000305}.
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DR   EMBL; AY923864; AAX93750.1; -; mRNA.
DR   AlphaFoldDB; Q29W25; -.
DR   SMR; Q29W25; -.
DR   Allergome; 2921; Cro s 1.
DR   Allergome; 3221; Cro s 1.0101.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   InterPro; IPR006040; Allergen_Ole_e_I_CS.
DR   InterPro; IPR006041; Pollen_Ole_e1_allergen.
DR   PANTHER; PTHR31614; PTHR31614; 1.
DR   PROSITE; PS00925; OLEEI; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000269|PubMed:26989701"
FT   CHAIN           27..168
FT                   /note="Pollen allergen Cro s 1"
FT                   /evidence="ECO:0000305|PubMed:26989701"
FT                   /id="PRO_5004206139"
FT   CARBOHYD        64
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   DISULFID        38..109
FT                   /evidence="ECO:0000250|UniProtKB:P19963"
FT   DISULFID        41..153
FT                   /evidence="ECO:0000250|UniProtKB:P19963"
FT   DISULFID        62..97
FT                   /evidence="ECO:0000250|UniProtKB:P19963"
FT   CONFLICT        27..28
FT                   /note="EN -> DQ (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        35
FT                   /note="M -> R (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   168 AA;  18289 MW;  FAA6CA76AEC6699C CRC64;
     MGKCQAVFLL VGALCVLSLA GVANAAENHF KVQGMVYCDT CRIQFMTRVS TIMEGATVKL
     ECRNITAGTQ TFKAEAVTDK VGQYSIPVHG DFQDDICEIE LVKSPNSECS EVSHDVYAKQ
     SAKVSLTSNN GEASDIRSAN ALGFMRKEPL KECPEVLKEL DLYDVKAN