ID   CRP2_GADMO              Reviewed;          25 AA.
AC   P86689;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   10-AUG-2010, sequence version 1.
DT   03-AUG-2022, entry version 14.
DE   RecName: Full=C-reactive protein P2 subunit 4;
DE   AltName: Full=C-reactive protein PII subunit 4 {ECO:0000303|PubMed:19081733};
DE   Flags: Fragment;
OS   Gadus morhua (Atlantic cod).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Zeiogadaria; Gadariae; Gadiformes; Gadoidei; Gadidae; Gadus.
OX   NCBI_TaxID=8049;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, GLYCOSYLATION,
RP   AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Serum {ECO:0000269|PubMed:19081733};
RX   PubMed=19081733; DOI=10.1016/j.fsi.2008.03.015;
RA   Gisladottir B., Gudmundsdottir S., Brown L., Jonsson Z.O., Magnadottir B.;
RT   "Isolation of two C-reactive protein homologues from cod (Gadus morhua L.)
RT   serum.";
RL   Fish Shellfish Immunol. 26:210-219(2009).
CC   -!- FUNCTION: Displays several functions associated with host defense: it
CC       promotes agglutination, bacterial capsular swelling, phagocytosis, and
CC       complement fixation through its calcium-dependent binding to
CC       phosphorylcholine. {ECO:0000250|UniProtKB:P02741,
CC       ECO:0000269|PubMed:19081733}.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000250|UniProtKB:P02741};
CC       Note=Binds 2 calcium ions per subunit. {ECO:0000250|UniProtKB:P02741};
CC   -!- SUBUNIT: Heteropentamer. Discoid arrangement of 5 non-covalently bound
CC       subunits 1, 2, 3 and 4. {ECO:0000269|PubMed:19081733}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19081733}.
CC   -!- PTM: Glycosylated. {ECO:0000269|PubMed:19081733}.
CC   -!- SIMILARITY: Belongs to the pentraxin family. {ECO:0000255}.
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DR   AlphaFoldDB; P86689; -.
DR   Proteomes; UP000694546; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   InterPro; IPR001759; Pentraxin-related.
DR   PROSITE; PS51828; PTX_2; 1.
PE   1: Evidence at protein level;
KW   Acute phase; Calcium; Direct protein sequencing; Metal-binding;
KW   Reference proteome; Secreted.
FT   CHAIN           1..>25
FT                   /note="C-reactive protein P2 subunit 4"
FT                   /id="PRO_0000397242"
FT   DOMAIN          1..>25
FT                   /note="Pentraxin (PTX)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT   NON_TER         25
FT                   /evidence="ECO:0000303|PubMed:19081733"
SQ   SEQUENCE   25 AA;  2781 MW;  84C0625AE3514202 CRC64;
     GRSLVFPEET ANSFVELFPA KELSL