ID   CRPI_PERAM              Reviewed;         685 AA.
AC   Q25641; Q94644;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Allergen Cr-PI;
DE   AltName: Allergen=Per a 3;
DE   Flags: Precursor;
OS   Periplaneta americana (American cockroach) (Blatta americana).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Blattidae;
OC   Blattinae; Periplaneta.
OX   NCBI_TaxID=6978;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8663281; DOI=10.1074/jbc.271.30.17937;
RA   Wu C.H.H., Lee M.F., Liao S.C.;
RT   "Sequencing analysis of cDNA clones encoding the American cockroach Cr-PI
RT   allergens. Homology with insect hemolymph proteins.";
RL   J. Biol. Chem. 271:17937-17943(1996).
CC   -!- FUNCTION: Larval storage protein (LSP) which may serve as a store of
CC       amino acids for synthesis of adult proteins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the hemocyanin family. {ECO:0000305}.
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DR   EMBL; L40818; AAB09629.1; -; mRNA.
DR   AlphaFoldDB; Q25641; -.
DR   SMR; Q25641; -.
DR   Allergome; 537; Per a 3.
DR   Allergome; 538; Per a 3.0101.
DR   PRIDE; Q25641; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1280.10; -; 1.
DR   Gene3D; 1.20.1370.10; -; 1.
DR   Gene3D; 2.60.40.1520; -; 1.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR013788; Hemocyanin/hexamerin.
DR   InterPro; IPR000896; Hemocyanin/hexamerin_mid_dom.
DR   InterPro; IPR005203; Hemocyanin_C.
DR   InterPro; IPR037020; Hemocyanin_C_sf.
DR   InterPro; IPR005204; Hemocyanin_N.
DR   InterPro; IPR036697; Hemocyanin_N_sf.
DR   InterPro; IPR014756; Ig_E-set.
DR   PANTHER; PTHR11511; PTHR11511; 1.
DR   Pfam; PF03723; Hemocyanin_C; 1.
DR   Pfam; PF00372; Hemocyanin_M; 1.
DR   Pfam; PF03722; Hemocyanin_N; 1.
DR   PRINTS; PR00187; HAEMOCYANIN.
DR   SUPFAM; SSF48050; SSF48050; 1.
DR   SUPFAM; SSF48056; SSF48056; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS00210; HEMOCYANIN_2; 1.
PE   1: Evidence at protein level;
KW   Allergen; Glycoprotein; Secreted; Signal; Storage protein.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..685
FT                   /note="Allergen Cr-PI"
FT                   /id="PRO_0000013339"
FT   CARBOHYD        233
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   685 AA;  81175 MW;  B596E0BC96149877 CRC64;
     MKTALVFAAV VAFVAARFPD HKDYKQLADK QFLAKQRDVL RLFHRVHQHN ILNDQVEVGI
     PMTSKQTSAT TVPPSGEAVH GVLQEGHARP RGEPFSVNYE KHREQAIMLY DLLYFANDYD
     TFYKTACWAR DRVNEGMFMY SFSIAVFHRD DMQGVMLPPP YEVYPYLFVD HDVIHMAQKY
     WMKNAGSGEH HSHVIPVNFT LRTQDHLLAY FTSDVNLNAF NTYYRYYYPS WYNTTLYGHN
     IDRRGEQFYY TYKQIYARYF LERLSNDLPD VYPFYYSKPV KSAYNPNLRY HNGEEMPVRP
     SNMYVTNFDL YYIADIKNYE KRVEDAIDFG YAFDEHMKPH SLYHDVHGME YLADMIEGNM
     DSPNFYFYGS IYHMYHSMIG HIVDPYHKMG LAPSLEHPET VLRDPVFYQL WKRVDHLFQK
     YKNRLPRYTH DELAFEGVKV ENVDVGKLYT YFEQYDMSLD MAVYVNNVDQ ISNVDVQLAV
     RLNHKPFTYN IEVSSDKAQD VYVAVFLGPK YDYLGREYDL NDRRHYFVEM DRFPYHVGAG
     KTVIERNSHD SNIIAPERDS YRTFYKKVQE AYEGKSQYYV DKGHNYCGYP ENLLIPKGKK
     GGQAYTFYVI VTPYVKQDEH DFEPYNYKAF SYCGVGSERK YPDNKPLGYP FDRKIYSNDF
     YTPNMYFKDV IIFHKKYDEV GVQGH