ID   CRPTI_RHIMP             Reviewed;          69 AA.
AC   P81162;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Protease inhibitor carrapatin;
OS   Rhipicephalus microplus (Cattle tick) (Boophilus microplus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Rhipicephalinae;
OC   Rhipicephalus; Boophilus.
OX   NCBI_TaxID=6941;
RN   [1]
RP   PROTEIN SEQUENCE.
RA   Fuentes-Prior P., Pereira P.J.B., Mentele R., Bode W.;
RL   Submitted (JAN-1998) to UniProtKB.
CC   -!- FUNCTION: Serine protease inhibitor.
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   AlphaFoldDB; P81162; -.
DR   SMR; P81162; -.
DR   MEROPS; I02.023; -.
DR   VEuPathDB; VectorBase:LOC119167313; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0044562; P:envenomation resulting in negative regulation of voltage-gated potassium channel activity in another organism; IEA:UniProt.
DR   CDD; cd00109; KU; 1.
DR   Gene3D; 4.10.410.10; -; 1.
DR   InterPro; IPR002223; Kunitz_BPTI.
DR   InterPro; IPR036880; Kunitz_BPTI_sf.
DR   InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR   Pfam; PF00014; Kunitz_BPTI; 1.
DR   PRINTS; PR00759; BASICPTASE.
DR   SMART; SM00131; KU; 1.
DR   SUPFAM; SSF57362; SSF57362; 1.
DR   PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR   PROSITE; PS50279; BPTI_KUNITZ_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Protease inhibitor; Secreted;
KW   Serine protease inhibitor.
FT   CHAIN           1..69
FT                   /note="Protease inhibitor carrapatin"
FT                   /id="PRO_0000155456"
FT   DOMAIN          8..58
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   SITE            18..19
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250"
FT   DISULFID        8..58
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        17..41
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        33..54
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
SQ   SEQUENCE   69 AA;  7842 MW;  E0B14312AC1533BB CRC64;
     AVDFDKQCVP TADPGPCKGF MPMWWYNIFT SQCEEFIYGG CQGNDNRYRT KEECDKTCAE
     ASATWDVNA