ID   CRP_MUSCA               Reviewed;          20 AA.
AC   P19094;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=C-reactive protein;
DE   Flags: Fragment;
OS   Mustelus canis (Smooth dogfish) (Squalus canis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Triakidae;
OC   Mustelus.
OX   NCBI_TaxID=7812;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
RX   PubMed=6403520; DOI=10.1016/s0021-9258(18)32750-9;
RA   Robey F.A., Tanaka T., Liu T.-Y.;
RT   "Isolation and characterization of two major serum proteins from the
RT   dogfish, Mustelus canis, C-reactive protein and amyloid P component.";
RL   J. Biol. Chem. 258:3889-3894(1983).
CC   -!- FUNCTION: Displays several functions associated with host defense: it
CC       promotes agglutination, bacterial capsular swelling, phagocytosis, and
CC       complement fixation through its calcium-dependent binding to
CC       phosphorylcholine. {ECO:0000269|PubMed:6403520}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. It is not known if it assembles
CC       into a pentraxin (or pentaxin) structure. Pentraxins have a discoid
CC       arrangement of 5 non-covalently bound subunits.
CC       {ECO:0000269|PubMed:6403520}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:6403520}.
CC   -!- PTM: Glycosylated.
CC   -!- SIMILARITY: Belongs to the pentraxin family. {ECO:0000305}.
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DR   PIR; A20569; A20569.
DR   AlphaFoldDB; P19094; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Acute phase; Calcium; Direct protein sequencing; Disulfide bond;
KW   Glycoprotein; Secreted.
FT   CHAIN           1..>20
FT                   /note="C-reactive protein"
FT                   /id="PRO_0000162501"
FT   DOMAIN          1..>20
FT                   /note="Pentraxin (PTX)"
FT   NON_TER         20
SQ   SEQUENCE   20 AA;  1966 MW;  2219495B977C4658 CRC64;
     SPVAASYRAT AGLAGKALDF