ID   CRP_PLEPL               Reviewed;          32 AA.
AC   P12245;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   11-DEC-2019, entry version 63.
DE   RecName: Full=C-reactive protein;
DE   Flags: Fragment;
OS   Pleuronectes platessa (European plaice).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Pleuronectidae;
OC   Pleuronectes.
OX   NCBI_TaxID=8262;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, AND
RP   GLYCOSYLATION.
RX   PubMed=7093286; DOI=10.1016/0167-4838(82)90139-x;
RA   Pepys M.B., de Beer F.C., Milstein C.P., March J.F., Feinstein A.,
RA   Butress N., Clamp J.R., Taylor J., Bruton C., Fletcher T.C.;
RT   "C-reactive protein and serum amyloid P component in the plaice
RT   (Pleuronectes platessa L.), a marine teleost, are homologous with their
RT   human counterparts.";
RL   Biochim. Biophys. Acta 704:123-133(1982).
CC   -!- FUNCTION: Displays several functions associated with host defense: it
CC       promotes agglutination, bacterial capsular swelling, phagocytosis, and
CC       complement fixation through its calcium-dependent binding to
CC       phosphorylcholine. {ECO:0000269|PubMed:7093286}.
CC   -!- SUBUNIT: Homopentamer. Pentraxin (or pentaxin) have a discoid
CC       arrangement of 5 non-covalently bound subunits.
CC       {ECO:0000269|PubMed:7093286}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7093286}.
CC   -!- PTM: Glycosylated. {ECO:0000269|PubMed:7093286}.
CC   -!- SIMILARITY: Belongs to the pentraxin family. {ECO:0000305}.
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DR   PIR; A05291; A05291.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   InterPro; IPR001759; Pentraxin-related.
DR   PROSITE; PS51828; PTX_2; 1.
PE   1: Evidence at protein level;
KW   Acute phase; Calcium; Direct protein sequencing; Secreted.
FT   CHAIN           1..>32
FT                   /note="C-reactive protein"
FT                   /id="PRO_0000162502"
FT   DOMAIN          2..>32
FT                   /note="Pentraxin (PTX)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT   NON_TER         32
SQ   SEQUENCE   32 AA;  3660 MW;  EDB2E0221D4FA227 CRC64;
     VVIKTLVFQS ESNNSFVELI PMKPLNLRAF XL