ID   CRR18_ARATH             Reviewed;         278 AA.
AC   Q9LRM1;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Cysteine-rich repeat secretory protein 18;
DE   Flags: Precursor;
GN   Name=CRRSP18; OrderedLocusNames=At3g21920; ORFNames=MZN24.4;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT   features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:131-135(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY ORGANIZATION, AND NOMENCLATURE.
RX   PubMed=11402176; DOI=10.1104/pp.126.2.473;
RA   Chen Z.;
RT   "A superfamily of proteins with novel cysteine-rich repeats.";
RL   Plant Physiol. 126:473-476(2001).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cysteine-rich repeat secretory protein
CC       family. {ECO:0000305}.
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DR   EMBL; AB028622; BAB01369.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE76566.1; -; Genomic_DNA.
DR   EMBL; BT003889; AAO41937.1; -; mRNA.
DR   EMBL; BT015914; AAU95450.1; -; mRNA.
DR   RefSeq; NP_188830.1; NM_113088.3.
DR   AlphaFoldDB; Q9LRM1; -.
DR   SMR; Q9LRM1; -.
DR   STRING; 3702.AT3G21920.1; -.
DR   PaxDb; Q9LRM1; -.
DR   EnsemblPlants; AT3G21920.1; AT3G21920.1; AT3G21920.
DR   GeneID; 821747; -.
DR   Gramene; AT3G21920.1; AT3G21920.1; AT3G21920.
DR   KEGG; ath:AT3G21920; -.
DR   Araport; AT3G21920; -.
DR   TAIR; locus:2095647; AT3G21920.
DR   eggNOG; ENOG502QPWH; Eukaryota.
DR   HOGENOM; CLU_000288_35_0_1; -.
DR   InParanoid; Q9LRM1; -.
DR   PhylomeDB; Q9LRM1; -.
DR   PRO; PR:Q9LRM1; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9LRM1; baseline.
DR   Genevisible; Q9LRM1; AT.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.30.430.20; -; 2.
DR   InterPro; IPR002902; GNK2.
DR   InterPro; IPR038408; GNK2_sf.
DR   Pfam; PF01657; Stress-antifung; 2.
DR   PROSITE; PS51473; GNK2; 2.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..278
FT                   /note="Cysteine-rich repeat secretory protein 18"
FT                   /id="PRO_0000296146"
FT   DOMAIN          39..147
FT                   /note="Gnk2-homologous 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00806"
FT   DOMAIN          160..267
FT                   /note="Gnk2-homologous 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00806"
SQ   SEQUENCE   278 AA;  31777 MW;  5B752C0E126DF588 CRC64;
     MYSSSSVSKR FVLVPIVVVV TTQLLLVRNV SSLNLTNSYL HHKCVVNQGK YKPGSKYEKS
     LDDIIQSFSN KDKDSYGFRT GYSMKAYGKE PDMVSITYQC RIDSRGPKCQ SCVVTAGYEL
     LRKRCPRYKE AIIWYDQCLV EFSSLDTSGQ INYDDNFCMP SAKNLIGNSI SLEERLHLLN
     NLTKIAVTKI DKNIEGIKKP VLYAAGEKRL GTKSLYGMVQ CSADLSVQGC NECMLYYIVH
     FQECWENKQG VRVLSRSCNF RYELYPFINP KGPYYTKF