CRS1_SCHPO
ID CRS1_SCHPO Reviewed; 300 AA.
AC O43008;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 3.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Meiosis-specific cyclin crs1;
DE AltName: Full=Cyclin-like protein regulated via splicing 1;
DE AltName: Full=Meiotically up-regulated gene 17 protein;
GN Name=crs1; Synonyms=mug17; ORFNames=SPBC2G2.09c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION IN MEIOSIS.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [3]
RP REVISION OF GENE MODEL.
RX PubMed=15893732; DOI=10.1016/j.molcel.2005.04.007;
RA Averbeck N., Sunder S., Sample N., Wise J.A., Leatherwood J.;
RT "Negative control contributes to an extensive program of meiotic splicing
RT in fission yeast.";
RL Mol. Cell 18:491-498(2005).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Has a role in meiotic chromosome segregation.
CC {ECO:0000269|PubMed:16303567}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
CC {ECO:0000305}.
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DR EMBL; CU329671; CAA17889.3; -; Genomic_DNA.
DR PIR; T40148; T40148.
DR RefSeq; NP_596438.3; NM_001022357.3.
DR AlphaFoldDB; O43008; -.
DR SMR; O43008; -.
DR BioGRID; 276978; 7.
DR STRING; 4896.SPBC2G2.09c.1; -.
DR PaxDb; O43008; -.
DR EnsemblFungi; SPBC2G2.09c.1; SPBC2G2.09c.1:pep; SPBC2G2.09c.
DR GeneID; 2540450; -.
DR KEGG; spo:SPBC2G2.09c; -.
DR PomBase; SPBC2G2.09c; crs1.
DR VEuPathDB; FungiDB:SPBC2G2.09c; -.
DR HOGENOM; CLU_080789_0_0_1; -.
DR InParanoid; O43008; -.
DR OMA; ITPESIW; -.
DR PRO; PR:O43008; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:1905263; P:positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination; IMP:PomBase.
DR GO; GO:1901993; P:regulation of meiotic cell cycle phase transition; NAS:PomBase.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR006671; Cyclin_N.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; SSF47954; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Chromosome partition; Cyclin; Cytoplasm;
KW Meiosis; Nucleus; Reference proteome.
FT CHAIN 1..300
FT /note="Meiosis-specific cyclin crs1"
FT /id="PRO_0000080417"
FT DOMAIN 61..183
FT /note="Cyclin N-terminal"
SQ SEQUENCE 300 AA; 34286 MW; 6B45063ACD929C2B CRC64;
MLTSKHEFSL FLNTPAINSK SEKEVISEGP LTTSNEIDVT FSESFSSHLI NLRRVPSVNS
IIEQEKKGLT KISPSILNQN IAYKEKRQQL FSVLYEETVG YVSMDTLCIA ISLLDRCFTV
KPTIPTTSFK IYAIGCLFIA FKLTSDYSVA KKSFCENLAP SLSTKNLEKY EKIVLALLNF
DIYVISLPSV ESFLTPLIFQ HVFFKSLPSE SCDQMMVEWQ YLLVEVMKDC QFIEYRPTEI
LCASFWVLLE IIWPSAFDFK PFQHLCSLPT NGSADETYIK HSNRFHDLII SIQRIADMLA
