ID   CRS5_YEAST              Reviewed;          69 AA.
AC   P41902; D6W296;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Metallothionein-like protein CRS5;
GN   Name=CRS5; OrderedLocusNames=YOR031W; ORFNames=O2675;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=XL2d.7-6;
RX   PubMed=7929222; DOI=10.1016/s0021-9258(18)47246-8;
RA   Culotta V.C., Howard W.R., Liu X.F.;
RT   "CRS5 encodes a metallothionein-like protein in Saccharomyces cerevisiae.";
RL   J. Biol. Chem. 269:25295-25302(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169874;
RA   Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA   Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA   Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA   Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA   Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA   Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA   Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA   Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA   Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA   Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA   Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA   Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA   Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA   Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA   Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA   Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA   Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL   Nature 387:98-102(1997).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
CC   -!- FUNCTION: Critical role in copper (specific) homeostasis and
CC       detoxification. May protect by directly chelating and sequestering
CC       copper ions.
CC   -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 13 family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene unlikely to encode a
CC       functional protein. Strain S288c has a stop codon in position 9, which
CC       disrupts the gene coding for this protein. Because of that it is not
CC       part of the S.cerevisiae S288c complete/reference proteome set.
CC       {ECO:0000305|PubMed:24374639}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=X87331; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC       Sequence=Z74939; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L29056; AAA66061.1; -; Genomic_DNA.
DR   EMBL; X87331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; Z74939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; A55011; A55011.
DR   AlphaFoldDB; P41902; -.
DR   SMR; P41902; -.
DR   BioGRID; 34433; 154.
DR   DIP; DIP-5511N; -.
DR   IntAct; P41902; 3.
DR   STRING; 4932.YOR031W; -.
DR   PaxDb; P41902; -.
DR   PRIDE; P41902; -.
DR   SGD; S000005557; CRS5.
DR   eggNOG; KOG4738; Eukaryota.
DR   HOGENOM; CLU_2777367_0_0_1; -.
DR   OMA; CKCETTC; -.
DR   GO; GO:0005737; C:cytoplasm; ISS:SGD.
DR   GO; GO:0005507; F:copper ion binding; IDA:SGD.
DR   GO; GO:0010038; P:response to metal ion; IMP:SGD.
DR   InterPro; IPR035715; Crs5.
DR   Pfam; PF12809; Metallothi_Euk2; 1.
PE   5: Uncertain;
KW   Copper; Metal-binding; Metal-thiolate cluster.
FT   CHAIN           1..69
FT                   /note="Metallothionein-like protein CRS5"
FT                   /id="PRO_0000197370"
SQ   SEQUENCE   69 AA;  7321 MW;  CEEF91203A813FF4 CRC64;
     MTVKICDCEG ECCKDSCHCG STCLPSCSGG EKCKCDHSTG SPQCKSCGEK CKCETTCTCE
     KSKCNCEKC