ID   CRSP1_BOVIN             Reviewed;         125 AA.
AC   Q75V95; Q17Q98;
DT   04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Calcitonin receptor-stimulating peptide 1;
DE            Short=CRSP-1;
DE   Flags: Precursor;
GN   Name=CRSP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND FUNCTION.
RC   TISSUE=Thyroid;
RX   PubMed=14672700; DOI=10.1016/j.bbrc.2003.11.114;
RA   Katafuchi T., Hamano K., Minamino N.;
RT   "Identification, structural determination, and biological activity of
RT   bovine and canine calcitonin receptor-stimulating peptides.";
RL   Biochem. Biophys. Res. Commun. 313:74-79(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=Hereford; TISSUE=Fetal medulla;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stimulates cAMP production in porcine kidney cell line LLC-
CC       PK1 via the calcitonin receptor (CT) but not via the CT-like (CL)
CC       receptor. {ECO:0000269|PubMed:14672700}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q75V95-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q75V95-2; Sequence=VSP_035622;
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   EMBL; AB125101; BAD05115.1; -; mRNA.
DR   EMBL; BC118475; AAI18476.1; -; mRNA.
DR   RefSeq; NP_001001149.1; NM_001001149.2. [Q75V95-1]
DR   RefSeq; NP_001128134.1; NM_001134662.1. [Q75V95-2]
DR   AlphaFoldDB; Q75V95; -.
DR   STRING; 9913.ENSBTAP00000001987; -.
DR   PaxDb; Q75V95; -.
DR   Ensembl; ENSBTAT00000001987; ENSBTAP00000001987; ENSBTAG00000001516. [Q75V95-2]
DR   GeneID; 407218; -.
DR   KEGG; bta:407218; -.
DR   CTD; 797; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001516; -.
DR   eggNOG; ENOG502SQMP; Eukaryota.
DR   GeneTree; ENSGT00940000166205; -.
DR   HOGENOM; CLU_1748985_0_0_1; -.
DR   InParanoid; Q75V95; -.
DR   OrthoDB; 1454612at2759; -.
DR   TreeFam; TF333069; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000001516; Expressed in thyroid gland and 25 other tissues.
DR   ExpressionAtlas; Q75V95; differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031716; F:calcitonin receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR015476; Calcitonin_gene-rel_peptide.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PANTHER; PTHR10505; PTHR10505; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00817; CALCITONINB.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cleavage on pair of basic residues; Disulfide bond;
KW   Receptor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..77
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000353070"
FT   PEPTIDE         80..125
FT                   /note="Calcitonin receptor-stimulating peptide 1"
FT                   /id="PRO_0000353071"
FT   DISULFID        81..86
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         76..125
FT                   /note="IQKRACNTATCMTHRLAGWLSRSGSMVRSNLLPTKMGFKIFNGPRRNSWF
FT                   -> PFLFLYAANQHPEESLQHCHLHDPSPGRLAEQIWEYGEEQLAADQDGFQDLQWAPQ
FT                   ELLVLNSEMTLGIRSPGS (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_035622"
SQ   SEQUENCE   125 AA;  14356 MW;  39929D89FB61CFD7 CRC64;
     MGFWKFPPFL VLSILVLYQA GMFHAAPFRS VFDGRFDPAT LDEEESRLLL AAMVNDYEQM
     RARESEKAQK TEGSRIQKRA CNTATCMTHR LAGWLSRSGS MVRSNLLPTK MGFKIFNGPR
     RNSWF