ID   CRSP1_CANLF             Reviewed;         127 AA.
AC   Q75V94;
DT   04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Calcitonin receptor-stimulating peptide 1;
DE            Short=CRSP-1;
DE   Flags: Precursor;
GN   Name=CRSP1;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   TISSUE=Thyroid;
RX   PubMed=14672700; DOI=10.1016/j.bbrc.2003.11.114;
RA   Katafuchi T., Hamano K., Minamino N.;
RT   "Identification, structural determination, and biological activity of
RT   bovine and canine calcitonin receptor-stimulating peptides.";
RL   Biochem. Biophys. Res. Commun. 313:74-79(2004).
CC   -!- FUNCTION: Stimulates cAMP production in porcine kidney cell line LLC-
CC       PK1 via the calcitonin receptor (CT) but not via the CT-like (CL)
CC       receptor. {ECO:0000269|PubMed:14672700}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB125102; BAD05116.1; -; mRNA.
DR   RefSeq; NP_001002948.1; NM_001002948.2.
DR   RefSeq; XP_013977886.1; XM_014122411.1.
DR   AlphaFoldDB; Q75V94; -.
DR   STRING; 9615.ENSCAFP00000012545; -.
DR   PaxDb; Q75V94; -.
DR   GeneID; 403415; -.
DR   KEGG; cfa:403415; -.
DR   CTD; 797; -.
DR   eggNOG; ENOG502SQMP; Eukaryota.
DR   HOGENOM; CLU_122444_1_0_1; -.
DR   InParanoid; Q75V94; -.
DR   OMA; STCVTHR; -.
DR   OrthoDB; 1547206at2759; -.
DR   TreeFam; TF333069; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031716; F:calcitonin receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR015476; Calcitonin_gene-rel_peptide.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PANTHER; PTHR10505; PTHR10505; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00817; CALCITONINB.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Receptor;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..79
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000353072"
FT   PEPTIDE         82..127
FT                   /note="Calcitonin receptor-stimulating peptide 1"
FT                   /id="PRO_0000353073"
FT   DISULFID        83..88
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   127 AA;  14275 MW;  5C296FD7F228966E CRC64;
     MGFWKFSPFL VLGILALYQV GFLQAAPFRS ALENPPDSGV RNEEELRLLL AAVMKDYMQM
     KTHELEQEQE TEGSRVAVQK RSCNSATCVA HWLGGLLSRA GSVANTNLLP TSMGFKVYNR
     RRRELKA