ID   CRSP1_CAPHI             Reviewed;         125 AA.
AC   B3IWF7;
DT   04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Calcitonin receptor-stimulating peptide 1;
DE            Short=CRSP-1;
DE   Flags: Precursor;
GN   Name=CRSP1;
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Charles C.J., Katafuchi T., Yandle T.G., Minamino N.;
RT   "Identification and biological activity of ovine and caprine calcitonin
RT   receptor-Sti.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stimulates cAMP production in porcine kidney cell line LLC-
CC       PK1 via the calcitonin receptor (CT) but not via the CT-like (CL)
CC       receptor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   EMBL; AB364646; BAG50395.1; -; mRNA.
DR   RefSeq; NP_001272563.1; NM_001285634.1.
DR   AlphaFoldDB; B3IWF7; -.
DR   STRING; 9925.ENSCHIP00000015856; -.
DR   Ensembl; ENSCHIT00000023661; ENSCHIP00000015856; ENSCHIG00000016334.
DR   GeneID; 100861290; -.
DR   KEGG; chx:100861290; -.
DR   CTD; 100861290; -.
DR   GeneTree; ENSGT00940000166205; -.
DR   OMA; STCVTHR; -.
DR   OrthoDB; 1547206at2759; -.
DR   Proteomes; UP000291000; Chromosome 15.
DR   Bgee; ENSCHIG00000016334; Expressed in ovary and 2 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR015476; Calcitonin_gene-rel_peptide.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PANTHER; PTHR10505; PTHR10505; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00817; CALCITONINB.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Receptor;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..77
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000353074"
FT   PEPTIDE         80..125
FT                   /note="Calcitonin receptor-stimulating peptide 1"
FT                   /id="PRO_0000353075"
FT   DISULFID        81..86
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   125 AA;  14361 MW;  23BB81F9EC51CFD7 CRC64;
     MGFWKFPPFL VLSILVLYQA GMFHAAPFRS VFDGRFDPAT LDEEESRLLL AAMVNDYEQM
     RARESEKAQK TEGSRIQKRA CNTATCMTHR LAGWLSRSGS MVRSNLLPTK MGFKIFSGPR
     KNFWF