ID   CRSP1_PIG               Reviewed;         126 AA.
AC   Q862B1;
DT   04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Calcitonin receptor-stimulating peptide 1;
DE            Short=CRSP-1;
DE   Flags: Precursor;
GN   Name=CRSP1; Synonyms=CRSP;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 81-118, MASS SPECTROMETRY,
RP   FUNCTION, AND TISSUE SPECIFICITY.
RC   TISSUE=Brain;
RX   PubMed=12556539; DOI=10.1074/jbc.m207970200;
RA   Katafuchi T., Kikumoto K., Hamano K., Kangawa K., Matsuo H., Minamino N.;
RT   "Calcitonin receptor-stimulating peptide, a new member of the calcitonin
RT   gene-related peptide family. Its isolation from porcine brain, structure,
RT   tissue distribution, and biological activity.";
RL   J. Biol. Chem. 278:12046-12054(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX   PubMed=18544925; DOI=10.1159/000124380;
RA   Rezaeian A.H., Katafuchi T., Yoshizawa M., Hiraiwa N., Saito T.,
RA   Nishibori M., Hamano K., Minamino N., Yasue H.;
RT   "Genomic organization, expression and evolution of porcine CRSP1, 2, and
RT   3.";
RL   Cytogenet. Genome Res. 121:41-49(2008).
CC   -!- FUNCTION: Stimulates cAMP production in porcine kidney cell line LLC-
CC       PK1 via the calcitonin receptor (CT) but not via the CT-like (CL)
CC       receptor. {ECO:0000269|PubMed:12556539}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Mainly expressed in the thyroid gland and CNS.
CC       Found in the nerve cells of cerebrum, hippocampus, hypothalamus,
CC       pons/midbrain and thalamus. {ECO:0000269|PubMed:12556539,
CC       ECO:0000269|PubMed:18544925}.
CC   -!- MASS SPECTROMETRY: Mass=4130.6; Mass_error=0.7; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:12556539};
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   EMBL; AB094586; BAC66702.1; -; mRNA.
DR   EMBL; AB164322; BAF36048.1; -; Genomic_DNA.
DR   RefSeq; NP_998907.1; NM_213742.1.
DR   AlphaFoldDB; Q862B1; -.
DR   PaxDb; Q862B1; -.
DR   GeneID; 396563; -.
DR   KEGG; ssc:396563; -.
DR   CTD; 797; -.
DR   eggNOG; ENOG502SQMP; Eukaryota.
DR   InParanoid; Q862B1; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031716; F:calcitonin receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR015476; Calcitonin_gene-rel_peptide.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PANTHER; PTHR10505; PTHR10505; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00817; CALCITONINB.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Receptor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..78
FT                   /id="PRO_0000353076"
FT   PEPTIDE         81..118
FT                   /note="Calcitonin receptor-stimulating peptide 1"
FT                   /id="PRO_0000353077"
FT   PROPEP          123..126
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000353078"
FT   MOD_RES         118
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        82..87
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   126 AA;  14240 MW;  1EBEEED28BF0D9A8 CRC64;
     MGFWKFPPFL VLSILVLYQA GMFHTAPMRS AFGSPFDPAT LSEEESRLLL AAMVNDYEQM
     KAREMQKQRA QGSGISVQKR SCNTATCMTH RLVGLLSRSG SMVRSNLLPT KMGFKVFGGR
     RRNFWI