ID   CRSP1_SHEEP             Reviewed;         125 AA.
AC   B3IWF9;
DT   04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 40.
DE   RecName: Full=Calcitonin receptor-stimulating peptide 1;
DE            Short=CRSP-1;
DE   Flags: Precursor;
GN   Name=CRSP1;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Charles C.J., Katafuchi T., Yandle T.G., Minamino N.;
RT   "Identification and biological activity of ovine and caprine calcitonin
RT   receptor-Sti.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stimulates cAMP production via the calcitonin receptor (CT)
CC       but not via the CT-like (CL) receptor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   EMBL; AB364648; BAG50397.1; -; mRNA.
DR   RefSeq; NP_001123627.1; NM_001130155.1.
DR   AlphaFoldDB; B3IWF9; -.
DR   Ensembl; ENSOART00020012021; ENSOARP00020009902; ENSOARG00020007826.
DR   GeneID; 100170328; -.
DR   KEGG; oas:100170328; -.
DR   CTD; 797; -.
DR   OrthoDB; 1547206at2759; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR015476; Calcitonin_gene-rel_peptide.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PANTHER; PTHR10505; PTHR10505; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00817; CALCITONINB.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Receptor;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..77
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000353079"
FT   PEPTIDE         80..125
FT                   /note="Calcitonin receptor-stimulating peptide 1"
FT                   /id="PRO_0000353080"
FT   DISULFID        81..86
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   125 AA;  14419 MW;  3FCB9D958B61CFC2 CRC64;
     MGFWKFPPFL VLSILVLYQA GMFHAAPFRS VFDGRFDPAT LDEEESRLLL AAMVNDYEQM
     RTRESEKAQK TEGSRIQKRA CNTATCMTHR LAGWLSRSGS MVRSNLLPTK MGFKIFSGPR
     RNFWF