ID   CRSP2_CANLF             Reviewed;         127 AA.
AC   Q75V93;
DT   04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Calcitonin receptor-stimulating peptide 2;
DE            Short=CRSP-2;
DE   Flags: Precursor;
GN   Name=CRSP2;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Thyroid;
RX   PubMed=14672700; DOI=10.1016/j.bbrc.2003.11.114;
RA   Katafuchi T., Hamano K., Minamino N.;
RT   "Identification, structural determination, and biological activity of
RT   bovine and canine calcitonin receptor-stimulating peptides.";
RL   Biochem. Biophys. Res. Commun. 313:74-79(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   EMBL; AB125103; BAD05117.1; -; mRNA.
DR   RefSeq; NP_001002947.1; NM_001002947.2.
DR   AlphaFoldDB; Q75V93; -.
DR   STRING; 9612.ENSCAFP00000031979; -.
DR   PaxDb; Q75V93; -.
DR   Ensembl; ENSCAFT00040037962; ENSCAFP00040033091; ENSCAFG00040020517.
DR   Ensembl; ENSCAFT00845041257; ENSCAFP00845032340; ENSCAFG00845023366.
DR   GeneID; 403414; -.
DR   KEGG; cfa:403414; -.
DR   CTD; 403414; -.
DR   VEuPathDB; HostDB:ENSCAFG00845023366; -.
DR   eggNOG; ENOG502RZI5; Eukaryota.
DR   GeneTree; ENSGT00940000162876; -.
DR   HOGENOM; CLU_122444_1_0_1; -.
DR   InParanoid; Q75V93; -.
DR   OrthoDB; 1547206at2759; -.
DR   Proteomes; UP000002254; Chromosome 21.
DR   Bgee; ENSCAFG00000008550; Expressed in hypothalamus and 18 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031716; F:calcitonin receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   PANTHER; PTHR10505; PTHR10505; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Receptor;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..79
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000353081"
FT   PEPTIDE         82..127
FT                   /note="Calcitonin receptor-stimulating peptide 2"
FT                   /id="PRO_0000353082"
FT   REGION          65..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..85
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        83..88
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   127 AA;  14088 MW;  3B13B052A4F0BC2F CRC64;
     MGFWKLSPFL AIGLLVMYQA GILQAAPFRS ALENPLESAT LTEDEICVLL TAVVKDYVQM
     KARELQQEQE TEGSSLTAQK SSCKDGPCVT NRLEGWLARA ERMVKNTFMP TDVDPEAFGH
     QHKELAA