ID   CRSP2_PIG               Reviewed;         117 AA.
AC   Q766Y7;
DT   04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Calcitonin receptor-stimulating peptide 2;
DE            Short=CRSP-2;
DE   Flags: Precursor;
GN   Name=CRSP2;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Hypothalamus;
RX   PubMed=12914769; DOI=10.1016/s0006-291x(03)01413-x;
RA   Katafuchi T., Hamano K., Kikumoto K., Minamino N.;
RT   "Identification of second and third calcitonin receptor-stimulating
RT   peptides in porcine brain.";
RL   Biochem. Biophys. Res. Commun. 308:445-451(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX   PubMed=18544925; DOI=10.1159/000124380;
RA   Rezaeian A.H., Katafuchi T., Yoshizawa M., Hiraiwa N., Saito T.,
RA   Nishibori M., Hamano K., Minamino N., Yasue H.;
RT   "Genomic organization, expression and evolution of porcine CRSP1, 2, and
RT   3.";
RL   Cytogenet. Genome Res. 121:41-49(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Mainly expressed in the thyroid gland and CNS.
CC       Found in the nerve cells of the cerebrum, hippocampus, hypothalamus,
CC       pons/midbrain and thalamus. Also detected in the glia-like cells of
CC       pons/midbrain and in meninx of tactus opticus.
CC       {ECO:0000269|PubMed:12914769, ECO:0000269|PubMed:18544925}.
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   EMBL; AB114133; BAC81765.1; -; mRNA.
DR   EMBL; AB164323; BAF36049.1; -; Genomic_DNA.
DR   RefSeq; NP_998912.1; NM_213747.1.
DR   RefSeq; XP_013849997.1; XM_013994543.1.
DR   AlphaFoldDB; Q766Y7; -.
DR   SMR; Q766Y7; -.
DR   STRING; 9823.ENSSSCP00000014228; -.
DR   PaxDb; Q766Y7; -.
DR   Ensembl; ENSSSCT00000014623; ENSSSCP00000014228; ENSSSCG00000013387.
DR   Ensembl; ENSSSCT00005069622; ENSSSCP00005043308; ENSSSCG00005043380.
DR   Ensembl; ENSSSCT00015098970; ENSSSCP00015040864; ENSSSCG00015073577.
DR   Ensembl; ENSSSCT00030048850; ENSSSCP00030022072; ENSSSCG00030035250.
DR   Ensembl; ENSSSCT00040098082; ENSSSCP00040043784; ENSSSCG00040071369.
DR   Ensembl; ENSSSCT00055055893; ENSSSCP00055044624; ENSSSCG00055028206.
DR   Ensembl; ENSSSCT00060010784; ENSSSCP00060003965; ENSSSCG00060008432.
DR   Ensembl; ENSSSCT00065031838; ENSSSCP00065013031; ENSSSCG00065023918.
DR   Ensembl; ENSSSCT00070018387; ENSSSCP00070015272; ENSSSCG00070009493.
DR   GeneID; 396574; -.
DR   KEGG; ssc:396574; -.
DR   CTD; 403414; -.
DR   eggNOG; ENOG502SQMP; Eukaryota.
DR   GeneTree; ENSGT00940000156267; -.
DR   HOGENOM; CLU_122444_1_0_1; -.
DR   InParanoid; Q766Y7; -.
DR   OMA; WFSHIST; -.
DR   OrthoDB; 1547206at2759; -.
DR   TreeFam; TF333069; -.
DR   Proteomes; UP000008227; Chromosome 2.
DR   Proteomes; UP000314985; Chromosome 2.
DR   Bgee; ENSSSCG00000013387; Expressed in amygdala and 20 other tissues.
DR   ExpressionAtlas; Q766Y7; baseline and differential.
DR   Genevisible; Q766Y7; SS.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031716; F:calcitonin receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR015476; Calcitonin_gene-rel_peptide.
DR   PANTHER; PTHR10505; PTHR10505; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00817; CALCITONINB.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Receptor;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..77
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000353085"
FT   PEPTIDE         80..117
FT                   /note="Calcitonin receptor-stimulating peptide 2"
FT                   /id="PRO_0000353086"
FT   DISULFID        81..86
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   117 AA;  12969 MW;  336BE05FD5201DF6 CRC64;
     MGFWKFPPFL VLSILVLYQA GMFHTAPVRL PLESSFDSAT LTEEEVSLLL VAMVKDYVQM
     KATVLEQESE DFSITAQEKS CNTASCVTHK MTGWLSRSGS VAKNNFMPTN VDSKILG