ID   CRSP3_PIG               Reviewed;         125 AA.
AC   Q766Y6;
DT   04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Calcitonin receptor-stimulating peptide 3;
DE            Short=CRSP-3;
DE   Flags: Precursor;
GN   Name=CRSP3;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Hypothalamus;
RX   PubMed=12914769; DOI=10.1016/s0006-291x(03)01413-x;
RA   Katafuchi T., Hamano K., Kikumoto K., Minamino N.;
RT   "Identification of second and third calcitonin receptor-stimulating
RT   peptides in porcine brain.";
RL   Biochem. Biophys. Res. Commun. 308:445-451(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX   PubMed=18544925; DOI=10.1159/000124380;
RA   Rezaeian A.H., Katafuchi T., Yoshizawa M., Hiraiwa N., Saito T.,
RA   Nishibori M., Hamano K., Minamino N., Yasue H.;
RT   "Genomic organization, expression and evolution of porcine CRSP1, 2, and
RT   3.";
RL   Cytogenet. Genome Res. 121:41-49(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Mainly expressed in the thyroid gland and CNS.
CC       Found in the nerve cells of cerebrum, hippocampus, hypothalamus,
CC       pons/midbrain and thalamus. {ECO:0000269|PubMed:12914769,
CC       ECO:0000269|PubMed:18544925}.
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB114134; BAC81766.1; -; mRNA.
DR   EMBL; AB164324; BAF36050.1; -; Genomic_DNA.
DR   RefSeq; NP_998911.1; NM_213746.1.
DR   RefSeq; XP_005661169.1; XM_005661112.2.
DR   RefSeq; XP_005661170.1; XM_005661113.2.
DR   RefSeq; XP_013849996.1; XM_013994542.1.
DR   AlphaFoldDB; Q766Y6; -.
DR   SMR; Q766Y6; -.
DR   STRING; 9823.ENSSSCP00000014226; -.
DR   PaxDb; Q766Y6; -.
DR   Ensembl; ENSSSCT00000014621; ENSSSCP00000014226; ENSSSCG00000013386.
DR   Ensembl; ENSSSCT00015070969; ENSSSCP00015028431; ENSSSCG00015053283.
DR   Ensembl; ENSSSCT00025097969; ENSSSCP00025043062; ENSSSCG00025071316.
DR   Ensembl; ENSSSCT00030048747; ENSSSCP00030022031; ENSSSCG00030035155.
DR   Ensembl; ENSSSCT00035096310; ENSSSCP00035040525; ENSSSCG00035071262.
DR   Ensembl; ENSSSCT00040097926; ENSSSCP00040043699; ENSSSCG00040071268.
DR   Ensembl; ENSSSCT00045026655; ENSSSCP00045018400; ENSSSCG00045015714.
DR   Ensembl; ENSSSCT00050008270; ENSSSCP00050003538; ENSSSCG00050006073.
DR   Ensembl; ENSSSCT00055055948; ENSSSCP00055044674; ENSSSCG00055028233.
DR   Ensembl; ENSSSCT00060010382; ENSSSCP00060003807; ENSSSCG00060008130.
DR   Ensembl; ENSSSCT00065031152; ENSSSCP00065012748; ENSSSCG00065023405.
DR   GeneID; 396573; -.
DR   KEGG; ssc:396573; -.
DR   CTD; 396573; -.
DR   eggNOG; ENOG502SQMP; Eukaryota.
DR   GeneTree; ENSGT00940000156267; -.
DR   HOGENOM; CLU_122444_1_0_1; -.
DR   InParanoid; Q766Y6; -.
DR   OMA; TCVTHKM; -.
DR   OrthoDB; 1547206at2759; -.
DR   TreeFam; TF333069; -.
DR   Proteomes; UP000008227; Chromosome 2.
DR   Proteomes; UP000314985; Unplaced.
DR   Bgee; ENSSSCG00000013386; Expressed in oocyte and 20 other tissues.
DR   Genevisible; Q766Y6; SS.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031716; F:calcitonin receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR015476; Calcitonin_gene-rel_peptide.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PANTHER; PTHR10505; PTHR10505; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00817; CALCITONINB.
DR   SMART; SM00113; CALCITONIN; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Receptor;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..77
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000353087"
FT   PEPTIDE         80..116
FT                   /note="Calcitonin receptor-stimulating peptide 3"
FT                   /id="PRO_0000353088"
FT   PROPEP          122..125
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000353089"
FT   MOD_RES         116
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        81..86
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   125 AA;  14036 MW;  6FE166F9D8907F8E CRC64;
     MGFWKFPPFL ILSILVLYQA GMLHAAPFRM ALGSSFDSAT LTEEEMSLLL VAMVKDYVQM
     KATVLEQETE DFSITTQERS CNTAICVTHK MAGWLSRSGS VVKNNFMPIN MGSKVLGRRR
     RQPQA