ID   CRSPL_HUMAN             Reviewed;         253 AA.
AC   Q9H3Y0;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 136.
DE   RecName: Full=Peptidase inhibitor R3HDML;
DE   AltName: Full=Cysteine-rich secretory protein R3HDML;
DE   Flags: Precursor;
GN   Name=R3HDML;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Putative serine protease inhibitor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
CC   -!- CAUTION: Despite its name, it does not contain a R3H domain.
CC       {ECO:0000305}.
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DR   EMBL; AL117382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC107048; AAI07049.1; -; mRNA.
DR   CCDS; CCDS13329.1; -.
DR   RefSeq; NP_848586.1; NM_178491.3.
DR   AlphaFoldDB; Q9H3Y0; -.
DR   SMR; Q9H3Y0; -.
DR   BioGRID; 126761; 5.
DR   IntAct; Q9H3Y0; 1.
DR   STRING; 9606.ENSP00000217043; -.
DR   GlyGen; Q9H3Y0; 1 site.
DR   BioMuta; R3HDML; -.
DR   DMDM; 74752628; -.
DR   MassIVE; Q9H3Y0; -.
DR   PaxDb; Q9H3Y0; -.
DR   PRIDE; Q9H3Y0; -.
DR   Antibodypedia; 76963; 35 antibodies from 10 providers.
DR   DNASU; 140902; -.
DR   Ensembl; ENST00000217043.4; ENSP00000217043.3; ENSG00000101074.5.
DR   GeneID; 140902; -.
DR   KEGG; hsa:140902; -.
DR   MANE-Select; ENST00000217043.4; ENSP00000217043.3; NM_178491.4; NP_848586.1.
DR   UCSC; uc002xls.3; human.
DR   CTD; 140902; -.
DR   DisGeNET; 140902; -.
DR   GeneCards; R3HDML; -.
DR   HGNC; HGNC:16249; R3HDML.
DR   HPA; ENSG00000101074; Tissue enriched (intestine).
DR   neXtProt; NX_Q9H3Y0; -.
DR   OpenTargets; ENSG00000101074; -.
DR   PharmGKB; PA34099; -.
DR   VEuPathDB; HostDB:ENSG00000101074; -.
DR   eggNOG; KOG3017; Eukaryota.
DR   GeneTree; ENSGT00940000161086; -.
DR   HOGENOM; CLU_035730_2_2_1; -.
DR   InParanoid; Q9H3Y0; -.
DR   OMA; KMGRPCS; -.
DR   OrthoDB; 1528782at2759; -.
DR   PhylomeDB; Q9H3Y0; -.
DR   TreeFam; TF316148; -.
DR   PathwayCommons; Q9H3Y0; -.
DR   SignaLink; Q9H3Y0; -.
DR   BioGRID-ORCS; 140902; 12 hits in 1059 CRISPR screens.
DR   ChiTaRS; R3HDML; human.
DR   GenomeRNAi; 140902; -.
DR   Pharos; Q9H3Y0; Tdark.
DR   PRO; PR:Q9H3Y0; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   RNAct; Q9H3Y0; protein.
DR   Bgee; ENSG00000101074; Expressed in mucosa of transverse colon and 20 other tissues.
DR   Genevisible; Q9H3Y0; HS.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0030414; F:peptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0010466; P:negative regulation of peptidase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Protease inhibitor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..56
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000287635"
FT   CHAIN           57..253
FT                   /note="Peptidase inhibitor R3HDML"
FT                   /id="PRO_0000287636"
FT   DOMAIN          67..207
FT                   /note="SCP"
FT   CARBOHYD        120
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         15
FT                   /note="F -> C (in dbSNP:rs11699901)"
FT                   /id="VAR_032339"
FT   VARIANT         68
FT                   /note="D -> N (in dbSNP:rs36117710)"
FT                   /id="VAR_048834"
SQ   SEQUENCE   253 AA;  28605 MW;  28976C6F32E3887E CRC64;
     MPLLPSTVGL AGLLFWAGQA VNALIMPNAT PAPAQPESTA MRLLSGLEVP RYRRKRHISV
     RDMNALLDYH NHIRASVYPP AANMEYMVWD KRLARAAEAW ATQCIWAHGP SQLMRYVGQN
     LSIHSGQYRS VVDLMKSWSE EKWHYLFPAP RDCNPHCPWR CDGPTCSHYT QMVWASSNRL
     GCAIHTCSSI SVWGNTWHRA AYLVCNYAIK GNWIGESPYK MGKPCSSCPP SYQGSCNSNM
     CFKGLKSNKF TWF