ID   CRSPL_MOUSE             Reviewed;         253 AA.
AC   A2A5I3;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Peptidase inhibitor R3HDML;
DE   AltName: Full=Cysteine-rich secretory protein R3HDML;
DE   Flags: Precursor;
GN   Name=R3hdml;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: Putative serine protease inhibitor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
CC   -!- CAUTION: Despite its name, it does not contain a R3H domain.
CC       {ECO:0000305}.
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DR   EMBL; AL591488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS38316.1; -.
DR   RefSeq; NP_001092801.1; NM_001099331.2.
DR   RefSeq; XP_006498585.1; XM_006498522.3.
DR   AlphaFoldDB; A2A5I3; -.
DR   SMR; A2A5I3; -.
DR   STRING; 10090.ENSMUSP00000105043; -.
DR   GlyGen; A2A5I3; 2 sites.
DR   MaxQB; A2A5I3; -.
DR   PaxDb; A2A5I3; -.
DR   PRIDE; A2A5I3; -.
DR   Antibodypedia; 76963; 35 antibodies from 10 providers.
DR   Ensembl; ENSMUST00000109416; ENSMUSP00000105043; ENSMUSG00000078949.
DR   GeneID; 100043899; -.
DR   KEGG; mmu:100043899; -.
DR   UCSC; uc008nsw.2; mouse.
DR   CTD; 140902; -.
DR   MGI; MGI:3650937; R3hdml.
DR   VEuPathDB; HostDB:ENSMUSG00000078949; -.
DR   eggNOG; KOG3017; Eukaryota.
DR   GeneTree; ENSGT00940000161086; -.
DR   HOGENOM; CLU_035730_2_2_1; -.
DR   InParanoid; A2A5I3; -.
DR   OMA; KMGRPCS; -.
DR   OrthoDB; 1528782at2759; -.
DR   PhylomeDB; A2A5I3; -.
DR   TreeFam; TF316148; -.
DR   BioGRID-ORCS; 100043899; 1 hit in 70 CRISPR screens.
DR   PRO; PR:A2A5I3; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; A2A5I3; protein.
DR   Bgee; ENSMUSG00000078949; Expressed in lens of camera-type eye and 14 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0030414; F:peptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0010466; P:negative regulation of peptidase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Protease inhibitor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..56
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000287637"
FT   CHAIN           57..253
FT                   /note="Peptidase inhibitor R3HDML"
FT                   /id="PRO_0000287638"
FT   DOMAIN          67..207
FT                   /note="SCP"
FT   CARBOHYD        28
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        120
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   253 AA;  28269 MW;  ECD1E2A41F341243 CRC64;
     MPLLSSIVGL TGLLLWMGHT VGALRMPNTT LVQGRPKNTA VWPLSGLGVP RHRRKRHISA
     RDMSALLDYH NHIRASVHPP AANMEYMVWD EQLARSAEAW ATQCIWTHGP SQLMKYVGQN
     LSIHSGRFRS VVDLVRSWSE EKRHYSFPAP KDCTPHCPWL CSGPVCSHYT QMVWASSSRL
     GCAINTCSSI NVWGNTWQQA VYLVCNYAIK GNWIGEAPYK AGKPCSACPP SYQGNCNSNM
     CFSGLKSNRL PWV