ID   CRTC_CERS4              Reviewed;         279 AA.
AC   Q01670; Q3J193;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 3.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Acyclic carotenoid 1,2-hydratase;
DE            EC=4.2.1.131;
DE   AltName: Full=Hydroxyneurosporene synthase;
DE   AltName: Full=Lycopene hydratase;
DE   AltName: Full=Neurosporene hydratase;
GN   Name=crtC; Synonyms=ctrC; OrderedLocusNames=RHOS4_18730; ORFNames=RSP_0267;
OS   Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG
OS   31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter
OS   sphaeroides).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Cereibacter.
OX   NCBI_TaxID=272943;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7721699; DOI=10.1128/jb.177.8.2064-2073.1995;
RA   Lang H.P., Cogdell R.J., Takaichi S., Hunter C.N.;
RT   "Complete DNA sequence, specific Tn5 insertion map, and gene assignment of
RT   the carotenoid biosynthesis pathway of Rhodobacter sphaeroides.";
RL   J. Bacteriol. 177:2064-2073(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203
RC   / NCIMB 8253 / ATH 2.4.1.;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C.,
RA   Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.;
RT   "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-44.
RX   PubMed=1612412; DOI=10.1016/0378-1097(92)90497-c;
RA   Gari E., Toledo J.C., Gibert I., Barbe J.;
RT   "Nucleotide sequence of the methoxyneurosporene dehydrogenase gene from
RT   Rhodobacter sphaeroides: comparison with other bacterial carotenoid
RT   dehydrogenases.";
RL   FEMS Microbiol. Lett. 72:103-108(1992).
CC   -!- FUNCTION: Involved in the biosynthesis of carotenoids spheroidene and
CC       spirilloxanthin. Catalyzes the hydration of neurosporene to the
CC       corresponding hydroxylated carotenoids 1-HO-neurosporene and that of
CC       lycopene to 1-HO-lycopene (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=rhodopin = all-trans-lycopene + H2O; Xref=Rhea:RHEA:31607,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15948, ChEBI:CHEBI:35331;
CC         EC=4.2.1.131;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-hydroxy-all-trans-1,2-dihydro-neurosporene = all-trans-
CC         neurosporene + H2O; Xref=Rhea:RHEA:54220, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:16833, ChEBI:CHEBI:138077; EC=4.2.1.131;
CC   -!- PATHWAY: Carotenoid biosynthesis; spheroidene biosynthesis.
CC   -!- SIMILARITY: Belongs to the CrtC hydratase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABA79441.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AJ010302; CAB38742.1; -; Genomic_DNA.
DR   EMBL; X63204; CAA44887.1; -; Genomic_DNA.
DR   EMBL; CP000143; ABA79441.2; ALT_INIT; Genomic_DNA.
DR   PIR; S49623; S49623.
DR   RefSeq; YP_353342.2; NC_007493.2.
DR   AlphaFoldDB; Q01670; -.
DR   STRING; 272943.RSP_0267; -.
DR   EnsemblBacteria; ABA79441; ABA79441; RSP_0267.
DR   KEGG; rsp:RSP_0267; -.
DR   PATRIC; fig|272943.9.peg.2211; -.
DR   eggNOG; COG5621; Bacteria.
DR   PhylomeDB; Q01670; -.
DR   UniPathway; UPA00683; -.
DR   Proteomes; UP000002703; Chromosome 1.
DR   GO; GO:0016836; F:hydro-lyase activity; ISS:UniProtKB.
DR   GO; GO:0016116; P:carotenoid metabolic process; ISS:UniProtKB.
DR   GO; GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0015979; P:photosynthesis; IEA:UniProtKB-KW.
DR   GO; GO:1901180; P:spheroidene biosynthetic process; ISS:UniProtKB.
PE   3: Inferred from homology;
KW   Carotenoid biosynthesis; Chlorophyll biosynthesis; Lyase; Photosynthesis;
KW   Reference proteome.
FT   CHAIN           1..279
FT                   /note="Acyclic carotenoid 1,2-hydratase"
FT                   /id="PRO_0000079366"
FT   CONFLICT        43..45
FT                   /note="RGR -> AA (in Ref. 1; CAB38742)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        44
FT                   /note="G -> A (in Ref. 3; CAA44887)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        232
FT                   /note="S -> A (in Ref. 1; CAB38742)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   279 AA;  31356 MW;  C9065F7A5AC30C11 CRC64;
     MIGFIGSVFS PWYRWSGRKE PQNHCCLNVA TYGPGGRFTM TDRGRAALRQ SPDTLTVGPS
     RMHWTGTQLI VEVNEISSPP LVSPVKGRIV LTPTGITDVE VTLKDDGSHI WRPFAPTARI
     EVDLTQGHRW HGHGYFDANF GTAALEADFR FWTWGRYPVA DGAACFYDAT RRDGSRLELG
     LHVAADGRAR LIQPPPEARF ARSRWLVERH TPADPGTRPR QVMSMLDAPF YSRAMVETTV
     FGQKTVGVHE ALDLRRFRSP LLMPMLAVRV PRRPGWSFS