ID   CRTI_SYNY4              Reviewed;         532 AA.
AC   P21134;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Phytoene dehydrogenase;
DE            EC=1.3.99.-;
DE   AltName: Full=Phytoene desaturase;
GN   Name=crtI;
OS   Synechocystis sp. (strain PCC 6714) (Aphanocapsa sp. (strain PCC 6714)).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1147;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2119326; DOI=10.1016/0378-1119(90)90170-v;
RA   Schmidt A., Sandmann G.;
RT   "Cloning and nucleotide sequence of the crtI gene encoding phytoene
RT   dehydrogenase from the cyanobacterium Aphanocapsa PCC6714.";
RL   Gene 91:113-117(1990).
CC   -!- FUNCTION: This enzyme converts phytoene into zeta-carotene via the
CC       intermediary of phytofluene by the symmetrical introduction of two
CC       double bonds at the C-11 and C-11' positions of phytoene.
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000305};
CC       Name=NADP(+); Xref=ChEBI:CHEBI:58349; Evidence={ECO:0000305};
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000305};
CC   -!- PATHWAY: Carotenoid biosynthesis; lycopene biosynthesis.
CC   -!- SIMILARITY: Belongs to the carotenoid/retinoid oxidoreductase family.
CC       {ECO:0000305}.
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DR   EMBL; M55647; AAA62573.1; -; Genomic_DNA.
DR   PIR; JN0084; JN0084.
DR   AlphaFoldDB; P21134; -.
DR   UniPathway; UPA00803; -.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016117; P:carotenoid biosynthetic process; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Carotenoid biosynthesis; FAD; Flavoprotein; NAD; Oxidoreductase.
FT   CHAIN           1..532
FT                   /note="Phytoene dehydrogenase"
FT                   /id="PRO_0000067699"
FT   REGION          497..532
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        509..523
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         22..49
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   532 AA;  56755 MW;  06296C65A914B19F CRC64;
     MLPAVGVDRP VGRRLQLHAR VQQGIGVRSI AWSRVQAVAL LAVVRDRQAA VQTPRVGQHQ
     AVVQRNRRRH VRRARQGVAD GRQHLGHARR AERDDLCVQE GGGDIEIQAL VRAFEQDGVE
     CELDPLALGL ADVSAAVGVI GQTGRRLQLL EFIGEDVHRQ AKTVRRPTQP GLIGGDGFGI
     ERQGLGLGED RGAVEAAAAI AGPRRDEDVQ VRGKGVFGRD PTRHVVVLEG AVPDEGIGRG
     EGLGEGRDAP RVQVVVAPAE GRLVAGVTQT ARQGQLVGQV IVDLAEHGEA VARLLVQVVV
     LGPGRIAGPV GVEVDIVRDV EGAHDPVQTT VVVVAQTHFQ RGLVQRLIGI EARGRIGRAV
     AVALHRASRA LDVADHRQIQ VIAQTMLQRR RHAIDVDAMG RILRRIELVR VVVLARIGDI
     AVQRRRDTVV LARVAPVAAA EQLHGQVGVR REIEGDSGPA GEQILVAETF TAARIDDGRN
     LGLGHAGDDR LEARQVARAR PGHEAAPCSA STASRTPTVS LRGPPTAASI AR