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CRTP2_DICDI
ID   CRTP2_DICDI             Reviewed;         484 AA.
AC   Q550A6;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Crt homolog 2;
DE   AltName: Full=Chloroquine resistance transporter paralog 2;
DE            Short=DdCRTp2;
GN   Name=crtp2; ORFNames=DDB_G0277321;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=15883156; DOI=10.1074/jbc.m503227200;
RA   Naude B., Brzostowski J.A., Kimmel A.R., Wellems T.E.;
RT   "Dictyostelium discoideum expresses a malaria chloroquine resistance
RT   mechanism upon transfection with mutant, but not wild-type, Plasmodium
RT   falciparum transporter PfCRT.";
RL   J. Biol. Chem. 280:25596-25603(2005).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=16987557; DOI=10.1016/j.molbiopara.2006.08.006;
RA   Sa J.M., Yamamoto M.M., Fernandez-Becerra C., de Azevedo M.F.,
RA   Papakrivos J., Naude B., Wellems T.E., Del Portillo H.A.;
RT   "Expression and function of pvcrt-o, a Plasmodium vivax ortholog of pfcrt,
RT   in Plasmodium falciparum and Dictyostelium discoideum.";
RL   Mol. Biochem. Parasitol. 150:219-228(2006).
CC   -!- FUNCTION: May regulate endogenous transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRT-like transporter family. {ECO:0000305}.
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DR   EMBL; AAFI02000019; EAL68847.1; -; Genomic_DNA.
DR   RefSeq; XP_642710.1; XM_637618.1.
DR   AlphaFoldDB; Q550A6; -.
DR   SMR; Q550A6; -.
DR   PaxDb; Q550A6; -.
DR   EnsemblProtists; EAL68847; EAL68847; DDB_G0277321.
DR   GeneID; 8620902; -.
DR   KEGG; ddi:DDB_G0277321; -.
DR   dictyBase; DDB_G0277321; crtp2.
DR   eggNOG; ENOG502QR5M; Eukaryota.
DR   HOGENOM; CLU_571661_0_0_1; -.
DR   InParanoid; Q550A6; -.
DR   OMA; FTMPLPY; -.
DR   PhylomeDB; Q550A6; -.
DR   PRO; PR:Q550A6; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR013936; CRT-like.
DR   InterPro; IPR017258; Transprt_Chloroquine.
DR   Pfam; PF08627; CRT-like; 1.
DR   PIRSF; PIRSF037671; Transprt_Chloroquine_res; 1.
PE   3: Inferred from homology;
KW   Cytoplasmic vesicle; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..484
FT                   /note="Crt homolog 2"
FT                   /id="PRO_0000385364"
FT   TOPO_DOM        1..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..94
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        116..128
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        150..154
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        176..178
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        200..210
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        232..244
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        266..328
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        329..349
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        350..355
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        356..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        379..382
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        404..484
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        206
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        302
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   484 AA;  53676 MW;  8A2EDABB6EE424EB CRC64;
     MSEEKLPLLS PLNENDIEND YKDENLKSDL DKLSNVKKQS IIQRFKDYLK NSISKQTATV
     LVYVVLYILS GVINSLLLKK VMNVFTNYGF FLNQLTNYGY VPIFGAIVLY KILFTNDIPK
     DTRSFPQWKF VIMGALDAVT GYFVVIGGIK TTGPLQQLLN QSVIPFTMLL SFIFLKERYS
     LIQLGGALII IGGVVVSLIP SLTGGNTSGN MLFYNFFYLI SMIPYAFSNV YKAIGFSTVE
     DMDVWYLQYF DALYQSLVGT VLFPINNWLP PPSDMKFNQV IPQLKAGGKC LGGINTLIEQ
     YNSTTGELLP TSCNYGDNLG CDNCHGAWVV VLIYMAVNVL YNVFILLVLK HAGATVFSIA
     NTLRLPLTNI AFSFKFIMGS DSNPFSGLSV AGLCIILLGL GGYRVGSMIK QKKEAAASAD
     SSSNTENKVI PKVFPTQFGE VSIIIKKKVP PKSQTHLRNQ FFGKLGITVP ESKLRNQNSI
     YGDQ
 
 
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