CRTP3_DICDI
ID CRTP3_DICDI Reviewed; 478 AA.
AC Q55C66;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Crt homolog 3;
DE AltName: Full=Chloroquine resistance transporter paralog 3;
DE Short=DdCRTp3;
GN Name=crtp3; ORFNames=DDB_G0270204;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP IDENTIFICATION.
RX PubMed=15883156; DOI=10.1074/jbc.m503227200;
RA Naude B., Brzostowski J.A., Kimmel A.R., Wellems T.E.;
RT "Dictyostelium discoideum expresses a malaria chloroquine resistance
RT mechanism upon transfection with mutant, but not wild-type, Plasmodium
RT falciparum transporter PfCRT.";
RL J. Biol. Chem. 280:25596-25603(2005).
RN [3]
RP IDENTIFICATION.
RX PubMed=16987557; DOI=10.1016/j.molbiopara.2006.08.006;
RA Sa J.M., Yamamoto M.M., Fernandez-Becerra C., de Azevedo M.F.,
RA Papakrivos J., Naude B., Wellems T.E., Del Portillo H.A.;
RT "Expression and function of pvcrt-o, a Plasmodium vivax ortholog of pfcrt,
RT in Plasmodium falciparum and Dictyostelium discoideum.";
RL Mol. Biochem. Parasitol. 150:219-228(2006).
CC -!- FUNCTION: May regulate endogenous transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CRT-like transporter family. {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72452.1; -; Genomic_DNA.
DR RefSeq; XP_646615.1; XM_641523.1.
DR AlphaFoldDB; Q55C66; -.
DR SMR; Q55C66; -.
DR STRING; 44689.DDB0232252; -.
DR PaxDb; Q55C66; -.
DR EnsemblProtists; EAL72452; EAL72452; DDB_G0270204.
DR GeneID; 8617587; -.
DR KEGG; ddi:DDB_G0270204; -.
DR dictyBase; DDB_G0270204; crtp3.
DR eggNOG; ENOG502QR5M; Eukaryota.
DR HOGENOM; CLU_571661_0_0_1; -.
DR InParanoid; Q55C66; -.
DR OMA; ESLECAC; -.
DR PhylomeDB; Q55C66; -.
DR PRO; PR:Q55C66; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR013936; CRT-like.
DR InterPro; IPR017258; Transprt_Chloroquine.
DR Pfam; PF08627; CRT-like; 1.
DR PIRSF; PIRSF037671; Transprt_Chloroquine_res; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..478
FT /note="Crt homolog 3"
FT /id="PRO_0000385365"
FT TOPO_DOM 1..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..83
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..124
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..149
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..178
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 200..205
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..322
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 344..352
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 353..373
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 374..376
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 398..478
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 296
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 478 AA; 52833 MW; 4E795DED8F0993EB CRC64;
MGSDERKPLL SINDGDDDFN HQDVSTKTPP IKKESLSNKF KSFLKKSMTK ETLPILIYVL
LYIISGVINV VLLKKLMIKF VNYGFFLSQI TNYGYLPIFL VAMWYKMYCT SDVPKETRNF
PQYKFVIMGL LDAINGFFVV IGGVSTSGPL QQLLNQAIIP FTMIASFIFL RERYSLFQLG
GAAVILGGVI VSLIPSLVGG SSGGNILFYN FFYLISVIPG ALSNVYKDIA FQSIDMDVWY
LQFWDCLYQS LFGSILFPVN NWLPPPATIK FTEIIPSMRD GALCLGGKNT ILPIFNGTTS
TLAFGSCGIN DNFVCDDCHN TWIIVLIYMT VNIAYNIFIL LVLKHAGATV YSIANTVILP
LTNIFFSIHF IMGAATTPFS ALSVAGLLLI LFGLGGYRIG SMIKKPPPDS KKDSEQQGGE
GGAGDGDSSD NKNNLGDSAE IPQQIQPKTQ LHLRNQFFGR LGIDIPESRY RATNIINN
