CRTQ_STAHJ
ID CRTQ_STAHJ Reviewed; 375 AA.
AC Q4L977;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=4,4'-diaponeurosporenoate glycosyltransferase;
DE EC=2.4.1.-;
GN Name=crtQ; OrderedLocusNames=SH0489;
OS Staphylococcus haemolyticus (strain JCSC1435).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=279808;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCSC1435;
RX PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA Hiramatsu K.;
RT "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT extreme plasticity of its genome and the evolution of human-colonizing
RT staphylococcal species.";
RL J. Bacteriol. 187:7292-7308(2005).
CC -!- FUNCTION: Catalyzes the glycosylation of 4,4'-diaponeurosporenoate,
CC i.e. the esterification of glucose at the C1'' position with the
CC carboxyl group of 4,4'-diaponeurosporenic acid, to form glycosyl-4,4'-
CC diaponeurosporenoate. This is a step in the biosynthesis of
CC staphyloxanthin, an orange pigment present in most staphylococci
CC strains (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Carotenoid biosynthesis; staphyloxanthin biosynthesis;
CC staphyloxanthin from farnesyl diphosphate: step 4/5.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. CrtQ
CC subfamily. {ECO:0000305}.
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DR EMBL; AP006716; BAE03798.1; -; Genomic_DNA.
DR RefSeq; WP_011274814.1; NC_007168.1.
DR AlphaFoldDB; Q4L977; -.
DR SMR; Q4L977; -.
DR STRING; 279808.SH0489; -.
DR CAZy; GT2; Glycosyltransferase Family 2.
DR EnsemblBacteria; BAE03798; BAE03798; SH0489.
DR KEGG; sha:SH0489; -.
DR eggNOG; COG0463; Bacteria.
DR HOGENOM; CLU_038143_1_0_9; -.
DR OMA; GWLGKPH; -.
DR OrthoDB; 724641at2; -.
DR UniPathway; UPA00029; UER00559.
DR Proteomes; UP000000543; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016117; P:carotenoid biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.90.550.10; -; 1.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR SUPFAM; SSF53448; SSF53448; 1.
PE 3: Inferred from homology;
KW Carotenoid biosynthesis; Cell membrane; Glycosyltransferase; Membrane;
KW Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..375
FT /note="4,4'-diaponeurosporenoate glycosyltransferase"
FT /id="PRO_0000284867"
FT TRANSMEM 7..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 375 AA; 42809 MW; 2B79BA3875162C7E CRC64;
MTKLESLLHA STGLSLISGY LMYNRRYLLS FDKKREGETT QSISVIIPAR NEEKRLPKLL
KSLSQQSMRV ECIVMDDDSN DRTAEIAREM GAKVYNVTYD NNGNTWIGKS YACYLGASYT
VSDILIFMDA DVELNNEHAL EAIIQSYARQ QYRGLMSIQP YHVVYKPYEH LSAMFNLMTV
VGTNSFSTLS KSKGESLAFG PVTVMNKSDY ILTQGHKNAA SHIIEGFSLG KAFQRCQLPV
TRFEGQGFVS FRMYEAGFKT MIEGWTKHLA VGASSTQPHI MMLIILWMVG CITSFSGLAL
SLFMKTLSFK RMALSYSLYT LQFIRLHRRV GRFSILFLAI NSILFLVFIL VYINSYRHIH
YTKQVKWKGR QFSIK
