ID   CRTW_PARS1              Reviewed;         242 AA.
AC   Q44261;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Beta-carotene ketolase;
DE            EC=1.14.99.63;
DE   AltName: Full=Beta-carotene oxygenase;
OS   Paracoccus sp. (strain PC1) (Alcaligenes sp. (strain PC1)).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Paracoccus; unclassified Paracoccus (in: Bacteria).
OX   NCBI_TaxID=365615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7733978; DOI=10.1006/bbrc.1995.1579;
RA   Misawa N., Kajiwara S., Kondo K., Yokoyama A., Satomi Y., Saito T.,
RA   Miki W., Ohtani T.;
RT   "Canthaxanthin biosynthesis by the conversion of methylene to keto groups
RT   in a hydrocarbon beta-carotene by a single gene.";
RL   Biochem. Biophys. Res. Commun. 209:867-876(1995).
CC   -!- FUNCTION: Converts beta-carotene to canthaxanthin via echinenone.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 AH2 + all-trans-beta-carotene + 2 O2 = 2 A + echinenone + 3
CC         H2O; Xref=Rhea:RHEA:55660, ChEBI:CHEBI:4746, ChEBI:CHEBI:13193,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499,
CC         ChEBI:CHEBI:17579; EC=1.14.99.63;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 AH2 + echinenone + 2 O2 = 2 A + canthaxanthin + 3 H2O;
CC         Xref=Rhea:RHEA:55664, ChEBI:CHEBI:3362, ChEBI:CHEBI:4746,
CC         ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:17499; EC=1.14.99.63;
CC   -!- PATHWAY: Carotenoid biosynthesis; astaxanthin biosynthesis.
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DR   EMBL; D58422; BAA09596.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q44261; -.
DR   BRENDA; 1.14.99.63; 15774.
DR   UniPathway; UPA00387; -.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016117; P:carotenoid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005804; FA_desaturase_dom.
DR   InterPro; IPR012171; Fatty_acid_desaturase.
DR   PANTHER; PTHR19353; PTHR19353; 1.
DR   Pfam; PF00487; FA_desaturase; 2.
PE   4: Predicted;
KW   Carotenoid biosynthesis; Oxidoreductase.
FT   CHAIN           1..242
FT                   /note="Beta-carotene ketolase"
FT                   /id="PRO_0000079371"
SQ   SEQUENCE   242 AA;  26939 MW;  077DA83F4AAD14E4 CRC64;
     MSGRKPGTTG DTIVNLGLTA AILLCWLVLH AFTLWLLDAA AHPLLAVLCL AGLTWLSVGL
     FIIAHDAMHG SVVPGRPRAN AAIGQLALWL YAGFSWPKLI AKHMTHHRHA GTDNDPDFGH
     GGPVRWYGSF VSTYFGWREG LLLPVIVTTY ALILGDRWMY VIFWPVPAVL ASIQIFVFGT
     WLPHRPGHDD FPDRHNARST GIGDPLSLLT CFHFGGYHHE HHLHPHVPWW RLPRTRKTGG
     RA