ID   CRTY_ARTPT              Reviewed;         309 AA.
AC   O07333;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Phytoene synthase;
DE            EC=2.5.1.32;
GN   Name=crtB; Synonyms=pys;
OS   Arthrospira platensis (Spirulina platensis).
OC   Bacteria; Cyanobacteria; Oscillatoriophycideae; Oscillatoriales;
OC   Microcoleaceae; Arthrospira.
OX   NCBI_TaxID=118562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=IAM M-135;
RA   Kawata Y., Yano S., Kojima H.;
RL   Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reaction from prephytoene diphosphate to
CC       phytoene.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2
CC         diphosphate; Xref=Rhea:RHEA:34475, ChEBI:CHEBI:27787,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:58756; EC=2.5.1.32;
CC   -!- PATHWAY: Carotenoid biosynthesis; phytoene biosynthesis; all-trans-
CC       phytoene from geranylgeranyl diphosphate: step 1/1.
CC   -!- SIMILARITY: Belongs to the phytoene/squalene synthase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB001284; BAA20384.1; -; Genomic_DNA.
DR   AlphaFoldDB; O07333; -.
DR   SMR; O07333; -.
DR   PRIDE; O07333; -.
DR   OMA; KLYCYRV; -.
DR   UniPathway; UPA00799; UER00773.
DR   GO; GO:0004311; F:farnesyltranstransferase activity; IEA:InterPro.
DR   GO; GO:0016767; F:geranylgeranyl-diphosphate geranylgeranyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016117; P:carotenoid biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd00683; Trans_IPPS_HH; 1.
DR   Gene3D; 1.10.600.10; -; 1.
DR   InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR   InterPro; IPR002060; Squ/phyt_synthse.
DR   InterPro; IPR019845; Squalene/phytoene_synthase_CS.
DR   InterPro; IPR044843; Trans_IPPS_bact-type.
DR   InterPro; IPR033904; Trans_IPPS_HH.
DR   Pfam; PF00494; SQS_PSY; 1.
DR   SFLD; SFLDG01212; Phytoene_synthase_like; 1.
DR   SFLD; SFLDG01018; Squalene/Phytoene_Synthase_Lik; 1.
DR   SUPFAM; SSF48576; SSF48576; 1.
DR   PROSITE; PS01044; SQUALEN_PHYTOEN_SYN_1; 1.
DR   PROSITE; PS01045; SQUALEN_PHYTOEN_SYN_2; 1.
PE   3: Inferred from homology;
KW   Carotenoid biosynthesis; Multifunctional enzyme; Transferase.
FT   CHAIN           1..309
FT                   /note="Phytoene synthase"
FT                   /id="PRO_0000067436"
SQ   SEQUENCE   309 AA;  35945 MW;  C42A1C6431604C75 CRC64;
     MLQLSKSPCM RTPATRSDSY ELCRQITAQY AKTFYLGTQL MPLAKRQAIW AIYVWCRRTD
     ELVDGPMASS TTLETLDHWE EQLESIFAGH PIEPVDVALV DTLGRFPLDI QPFRDMIAGQ
     RMDLSRNRYN TFDELNLYCY RVAGTVGLMS LAVMGTAEPD LSVPWNRDQS IYYPKEEAIA
     LGIANQLTNI LRDVGEDARR GRIYLPLDDL ALFNYTEADL LNGKVDERWR ELMRFQIQRA
     RKFYTLAEEG IAALHPDIRW PVWTALMLYR QILDEIERNE YDVFNQRAYV PTWKKMMCLP
     LAQLRARVL