ID   CRTZ_PSEVU              Reviewed;         176 AA.
AC   Q01332;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Beta-carotene hydroxylase;
DE            EC=1.-.-.-;
GN   Name=crtZ; Synonyms=crtH;
OS   Pseudescherichia vulneris (Escherichia vulneris).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Pseudescherichia.
OX   NCBI_TaxID=566;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 39368 / Eho10;
RX   PubMed=8422926; DOI=10.1016/0014-5793(93)81188-6;
RA   Hundle B.S., O'Brien D.A., Beyer P., Kleinig H., Hearst J.E.;
RT   "In vitro expression and activity of lycopene cyclase and beta-carotene
RT   hydroxylase from Erwinia herbicola.";
RL   FEBS Lett. 315:329-334(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 39368 / Eho10;
RX   PubMed=7808389; DOI=10.1007/bf00302252;
RA   Hundle B., Alberti M., Nievelstein V., Beyer P., Kleinig H.,
RA   Armstrong G.A., Burke D.H., Hearst J.E.;
RT   "Functional assignment of Erwinia herbicola Eho10 carotenoid genes
RT   expressed in Escherichia coli.";
RL   Mol. Gen. Genet. 245:406-416(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 39368 / Eho10;
RA   Liu S.T.;
RL   Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the hydroxylation reaction from beta-carotene to
CC       zeaxanthin.
CC   -!- PATHWAY: Carotenoid biosynthesis; zeaxanthin biosynthesis.
CC   -!- SIMILARITY: Belongs to the sterol desaturase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M87280; AAA64983.1; -; Genomic_DNA.
DR   EMBL; L17139; AAA24816.1; -; Genomic_DNA.
DR   PIR; S52982; S52982.
DR   RefSeq; WP_042387980.1; NZ_UGGL01000002.1.
DR   AlphaFoldDB; Q01332; -.
DR   UniPathway; UPA00843; -.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016117; P:carotenoid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR045019; BETA-OHASE-like.
DR   InterPro; IPR006694; Fatty_acid_hydroxylase.
DR   PANTHER; PTHR31899; PTHR31899; 1.
DR   Pfam; PF04116; FA_hydroxylase; 1.
PE   3: Inferred from homology;
KW   Carotenoid biosynthesis; Oxidoreductase.
FT   CHAIN           1..176
FT                   /note="Beta-carotene hydroxylase"
FT                   /id="PRO_0000079378"
FT   DOMAIN          10..126
FT                   /note="Fatty acid hydroxylase"
FT                   /evidence="ECO:0000255"
FT   REGION          152..176
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   176 AA;  19966 MW;  BDE0A1C8A53F7BA8 CRC64;
     MLVNSLIVIL SVIAMEGIAA FTHRYIMHGW GWRWHESHHT PRKGVFELND LFAVVFAGVA
     IALIAVGTAG VWPLQWIGCG MTVYGLLYFL VHDGLVHQRW PFHWIPRRGY LKRLYVAHRL
     HHAVRGREGC VSFGFIYARK PADLQAILRE RHGRPPKRDA AKDRPDAASP SSSSPE