ID   CRT_PLACH               Reviewed;         424 AA.
AC   Q7Z0V9;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Putative chloroquine resistance transporter;
DE   AltName: Full=Probable transporter cg10;
DE            Short=pccg10;
DE   AltName: Full=pfcrt homolog;
GN   Name=CG10;
OS   Plasmodium chabaudi.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Vinckeia).
OX   NCBI_TaxID=5825;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=14668009; DOI=10.1016/j.molbiopara.2003.08.010;
RA   Hunt P., Cravo P.V., Donleavy P., Carlton J.M.-R., Walliker D.;
RT   "Chloroquine resistance in Plasmodium chabaudi: are chloroquine-resistance
RT   transporter (crt) and multi-drug resistance (mdr1) orthologues involved?";
RL   Mol. Biochem. Parasitol. 133:27-35(2004).
CC   -!- FUNCTION: May regulate endogenous transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane; Multi-pass membrane protein.
CC       Note=Localizes to the parasite digestive vacuole, the site of
CC       chloroquine action. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRT-like transporter family. {ECO:0000305}.
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DR   EMBL; AY304549; AAP68830.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q7Z0V9; -.
DR   SMR; Q7Z0V9; -.
DR   VEuPathDB; PlasmoDB:PCHAS_1220200; -.
DR   eggNOG; ENOG502QR5M; Eukaryota.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR013936; CRT-like.
DR   InterPro; IPR017258; Transprt_Chloroquine.
DR   PANTHER; PTHR31326; PTHR31326; 1.
DR   Pfam; PF08627; CRT-like; 1.
DR   PIRSF; PIRSF037671; Transprt_Chloroquine_res; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Transmembrane; Transmembrane helix; Vacuole.
FT   CHAIN           1..424
FT                   /note="Putative chloroquine resistance transporter"
FT                   /id="PRO_0000385357"
FT   TOPO_DOM        1..56
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..88
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        110..125
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        147..156
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        178..180
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        202..209
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        231..248
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        270..317
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        339..346
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        368..377
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        399..424
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        86
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   424 AA;  48579 MW;  412D844286A1F0B3 CRC64;
     MTGMKKGKNK KKNVKNDERY KELDSLISND SEIGNNSRWG GAKRICKLIG NEMRNNIYVY
     LLSILYLCVS VMNKVFSKRT LNKIGNYSFV TSEVHNMICT IVFQLLYFIY RKTSNPASRN
     ESQKNFGWQF FLISLLDAST VIITMIGLTR TTGNIQSFIM QLIIPVNMYF CFIFLGYRYH
     LFNYLGAFII LITIAAVETV LSYETQSDNS IIFNLIMIFA LIPLSFSNMT REVVFKKHKI
     NIIRLNAMVA LFQFFTSLLV LPVYNISFLK EIYMPFSEMG TNINDGLRCL FYGQSTIVEN
     CGVGMVKMCD QCEGAWKTFI TYSFFNICDN LLVCYIIDKF STMTYTIVSC IQGPAITIAY
     YFKFLAGDVV RQPRLLDFLT LFGYLLGTII YRIGNIILEK KKMLKALNTD GSEAELTSIE
     TSTA