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CRT_THEAN
ID   CRT_THEAN               Reviewed;         430 AA.
AC   Q4UDS9;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Putative chloroquine resistance transporter;
DE   AltName: Full=Probable transporter cg10;
GN   ORFNames=TA12005;
OS   Theileria annulata.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Theileriidae; Theileria.
OX   NCBI_TaxID=5874;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ankara;
RX   PubMed=15994557; DOI=10.1126/science.1110418;
RA   Pain A., Renauld H., Berriman M., Murphy L., Yeats C.A., Weir W.,
RA   Kerhornou A., Aslett M., Bishop R., Bouchier C., Cochet M., Coulson R.M.R.,
RA   Cronin A., de Villiers E.P., Fraser A., Fosker N., Gardner M., Goble A.,
RA   Griffiths-Jones S., Harris D.E., Katzer F., Larke N., Lord A., Maser P.,
RA   McKellar S., Mooney P., Morton F., Nene V., O'Neil S., Price C.,
RA   Quail M.A., Rabbinowitsch E., Rawlings N.D., Rutter S., Saunders D.,
RA   Seeger K., Shah T., Squares R., Squares S., Tivey A., Walker A.R.,
RA   Woodward J., Dobbelaere D.A.E., Langsley G., Rajandream M.A., McKeever D.,
RA   Shiels B., Tait A., Barrell B.G., Hall N.;
RT   "Genome of the host-cell transforming parasite Theileria annulata compared
RT   with T. parva.";
RL   Science 309:131-133(2005).
CC   -!- FUNCTION: May regulate endogenous transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane; Multi-pass membrane protein.
CC       Note=Localizes to the parasite digestive vacuole, the site of
CC       chloroquine action. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRT-like transporter family. {ECO:0000305}.
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DR   EMBL; CR940348; CAI74760.1; -; Genomic_DNA.
DR   RefSeq; XP_952492.1; XM_947399.1.
DR   AlphaFoldDB; Q4UDS9; -.
DR   SMR; Q4UDS9; -.
DR   STRING; 5874.XP_952492.1; -.
DR   GeneID; 3861985; -.
DR   KEGG; tan:TA12005; -.
DR   VEuPathDB; PiroplasmaDB:TA12005; -.
DR   eggNOG; ENOG502QR5M; Eukaryota.
DR   InParanoid; Q4UDS9; -.
DR   OMA; IWPALMI; -.
DR   OrthoDB; 630915at2759; -.
DR   Proteomes; UP000001950; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR013936; CRT-like.
DR   InterPro; IPR017258; Transprt_Chloroquine.
DR   Pfam; PF08627; CRT-like; 1.
DR   PIRSF; PIRSF037671; Transprt_Chloroquine_res; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Vacuole.
FT   CHAIN           1..430
FT                   /note="Putative chloroquine resistance transporter"
FT                   /id="PRO_0000385362"
FT   TOPO_DOM        1..53
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        75..88
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        110..122
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        144..147
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        169..173
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        195..206
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        224..239
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..306
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        307..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        330..335
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        336..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        359..364
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        386..430
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        195
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   430 AA;  48721 MW;  701B8C07228E66CC CRC64;
     MLKEGSSLDL SASSSSGTLR SDNSFGNSPL DRITSLLILI YKSIRACFKW IYSKSFGIIC
     ILFVILDVLT TVFFKRFIDH TKNYVMFTIQ VIIFTFWIIV CCIAILCFLF NREYMKRHFN
     VRPLVFLGFL DMLSTGLSAN GSAHTSGLML VLLGQISVPL TMVSCKLILS KKYHHYQYIS
     SAIILTFAVL KPILNRTDTT DNRFYNNMLY LLASVPDSIA SALREKQYTS KFFHVVKYQF
     FGFLFHFFYN ILYTLLFTLP FNSVKGYFDS LYKLCVNGYK CIFFGVNTIT ENCGPTLIPT
     CDNCLEAFKI YCLYILFSSA IRVAYVFIML DGSVTFTLLL GTVKVPLTSI AFSLRFIAGD
     STTSFNLLDV VCFLGIVAGL LLYALGSKKI QEETDLLESP LIDDAESEHE LLSTGTEKLM
     RSEICHDLFT
 
 
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