ID   CRVP7_VARAC             Reviewed;         158 AA.
AC   Q2XXQ8;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Cysteine-rich venom protein VAR7;
DE            Short=CRVP;
DE   AltName: Full=Cysteine-rich secretory protein VAR7;
DE            Short=CRISP-VAR7;
DE   Flags: Precursor; Fragment;
OS   Varanus acanthurus (Ridge-tailed monitor).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Anguimorpha; Paleoanguimorpha; Varanoidea; Varanidae; Varanus.
OX   NCBI_TaxID=62035;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=16292255; DOI=10.1038/nature04328;
RA   Fry B.G., Vidal N., Norman J.A., Vonk F.J., Scheib H., Ramjan S.F.R.,
RA   Kuruppu S., Fung K., Blair Hedges S., Richardson M.K., Hodgson W.C.,
RA   Ignjatovic V., Summerhayes R., Kochva E.;
RT   "Early evolution of the venom system in lizards and snakes.";
RL   Nature 439:584-588(2006).
CC   -!- FUNCTION: Blocks ryanodine receptors, and potassium channels.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- PTM: Contains 8 disulfide bonds. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR   EMBL; DQ139887; AAZ75593.1; -; mRNA.
DR   AlphaFoldDB; Q2XXQ8; -.
DR   SMR; Q2XXQ8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd05383; CAP_CRISP; 1.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR034117; SCP_CRISP.
DR   InterPro; IPR002413; V5_allergen-like.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00838; V5ALLERGEN.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
DR   PROSITE; PS01009; CRISP_1; 1.
PE   2: Evidence at transcript level;
KW   Calcium channel impairing toxin; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Potassium channel impairing toxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..>158
FT                   /note="Cysteine-rich venom protein VAR7"
FT                   /id="PRO_0000380658"
FT   DOMAIN          41..158
FT                   /note="SCP"
FT   DISULFID        77..156
FT                   /evidence="ECO:0000250"
FT   NON_TER         158
SQ   SEQUENCE   158 AA;  17936 MW;  0DF09C27BA28A0DA CRC64;
     MILLKLYLTL AAILCQSRGT TSLDLDDLMT TNPEIQNEII NKHNDLRRTV DPPAKNMLKM
     SWDNTIAESA KRAALRCNQN EHTPVSGRTI GGVVCGENYF MSSNLRTWSF GIQSWFDERN
     YFKFGFGPTR AGVMVGHYTQ VVWYKSYKMG CAINLCPN