ID   CRVP8_VARAC             Reviewed;         200 AA.
AC   Q2XXQ7;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Cysteine-rich venom protein VAR8;
DE            Short=CRVP;
DE   AltName: Full=Cysteine-rich secretory protein VAR8;
DE            Short=CRISP-VAR8;
DE   Flags: Precursor; Fragment;
OS   Varanus acanthurus (Ridge-tailed monitor).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Anguimorpha; Paleoanguimorpha; Varanoidea; Varanidae; Varanus.
OX   NCBI_TaxID=62035;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=16292255; DOI=10.1038/nature04328;
RA   Fry B.G., Vidal N., Norman J.A., Vonk F.J., Scheib H., Ramjan S.F.R.,
RA   Kuruppu S., Fung K., Blair Hedges S., Richardson M.K., Hodgson W.C.,
RA   Ignjatovic V., Summerhayes R., Kochva E.;
RT   "Early evolution of the venom system in lizards and snakes.";
RL   Nature 439:584-588(2006).
CC   -!- FUNCTION: Blocks ryanodine receptors, and potassium channels.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- PTM: Contains 8 disulfide bonds. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR   EMBL; DQ139888; AAZ75594.1; -; mRNA.
DR   AlphaFoldDB; Q2XXQ7; -.
DR   SMR; Q2XXQ7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd05383; CAP_CRISP; 1.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR034117; SCP_CRISP.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
DR   PROSITE; PS01009; CRISP_1; 1.
DR   PROSITE; PS01010; CRISP_2; 1.
PE   2: Evidence at transcript level;
KW   Calcium channel impairing toxin; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Potassium channel impairing toxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..>200
FT                   /note="Cysteine-rich venom protein VAR8"
FT                   /id="PRO_0000380659"
FT   DOMAIN          41..169
FT                   /note="SCP"
FT   DISULFID        77..156
FT                   /evidence="ECO:0000250"
FT   DISULFID        95..170
FT                   /evidence="ECO:0000250"
FT   DISULFID        151..167
FT                   /evidence="ECO:0000250"
FT   DISULFID        189..196
FT                   /evidence="ECO:0000250"
FT   NON_TER         200
SQ   SEQUENCE   200 AA;  22485 MW;  1D61236FCDB55D40 CRC64;
     MILLKLYLTL AAILCQSRGT TSLDLDDLMT TNPEIQNEII NKHNDLRRTV DPPAKNMLKM
     SWDNTIAESA KRAALRCNQN EHTPVSGRTI GGVVCGENYF MSSNLRTWSF GIQSWFDERN
     YFKFGFGPTR AGVMVGHYTQ VVWYKSYKMG CAINLCPNEP LKYFLVCQYC PGGNVVGRKY
     EPYAIGEPCA ACPNNCDNGL