ID   CRVP9_VARVA             Reviewed;         102 AA.
AC   Q2XXP3;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Cysteine-rich venom protein VAR9;
DE            Short=CRVP;
DE   AltName: Full=Cysteine-rich secretory protein VAR9;
DE            Short=CRISP-VAR9;
DE   Flags: Precursor; Fragment;
OS   Varanus varius (Lace monitor).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Anguimorpha; Paleoanguimorpha; Varanoidea; Varanidae; Varanus.
OX   NCBI_TaxID=8559;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=16292255; DOI=10.1038/nature04328;
RA   Fry B.G., Vidal N., Norman J.A., Vonk F.J., Scheib H., Ramjan S.F.R.,
RA   Kuruppu S., Fung K., Blair Hedges S., Richardson M.K., Hodgson W.C.,
RA   Ignjatovic V., Summerhayes R., Kochva E.;
RT   "Early evolution of the venom system in lizards and snakes.";
RL   Nature 439:584-588(2006).
CC   -!- FUNCTION: Blocks ryanodine receptors, and potassium channels.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- PTM: Contains 8 disulfide bonds. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ139902; AAZ75608.1; -; mRNA.
DR   AlphaFoldDB; Q2XXP3; -.
DR   SMR; Q2XXP3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
PE   2: Evidence at transcript level;
KW   Calcium channel impairing toxin; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Potassium channel impairing toxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..>102
FT                   /note="Cysteine-rich venom protein VAR9"
FT                   /id="PRO_0000380660"
FT   DOMAIN          41..80
FT                   /note="SCP"
FT   NON_TER         102
SQ   SEQUENCE   102 AA;  11533 MW;  1F0A1EC72D288868 CRC64;
     MILLKLYLTL AAILCQSRGM TSLDLDDLMT TNPEIQNEII NKHNDLRRTV DPPAKNMLKM
     SWDNIIAESA KRAALRCNYK EHTSIAERTI GGCGVWEKIL SC