ID   CRVPA_NAJHA             Reviewed;          30 AA.
AC   P0DL14;
DT   01-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2013, sequence version 1.
DT   23-FEB-2022, entry version 15.
DE   RecName: Full=Cysteine-rich venom protein annuliferin-a;
DE            Short=CRVP;
DE   Flags: Fragment;
OS   Naja annulifera (Banded Egyptian cobra) (Naja haje annulifera).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX   NCBI_TaxID=96794;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Venom;
RX   PubMed=19106157; DOI=10.1093/jb/mvn174;
RA   Matsunaga Y., Yamazaki Y., Hyodo F., Sugiyama Y., Nozaki M., Morita T.;
RT   "Structural divergence of cysteine-rich secretory proteins in snake
RT   venoms.";
RL   J. Biochem. 145:365-375(2009).
CC   -!- FUNCTION: Inhibits calcium-activated potassium channels (KCa), voltage-
CC       gated potassium channel (Kv), and the calcium release channel/ryanodine
CC       receptor (RyR). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- PTM: Contains 8 disulfide bonds. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Calcium channel impairing toxin;
KW   Calcium-activated potassium channel impairing toxin;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Potassium channel impairing toxin;
KW   Ryanodine-sensitive calcium-release channel impairing toxin; Secreted;
KW   Toxin; Voltage-gated potassium channel impairing toxin.
FT   CHAIN           1..>30
FT                   /note="Cysteine-rich venom protein annuliferin-a"
FT                   /id="PRO_0000422144"
FT   NON_TER         30
SQ   SEQUENCE   30 AA;  3649 MW;  CC8E377A54052E1F CRC64;
     NVDFNSESTR RKKKQKEIVD LHNXLRRXVD