ID   CRVP_BUNCA              Reviewed;          67 AA.
AC   P81993;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2004, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Cysteine-rich venom protein bucarin;
DE   Flags: Fragment;
OS   Bungarus candidus (Malayan krait).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Bungarinae; Bungarus.
OX   NCBI_TaxID=92438 {ECO:0000305};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE.
RC   TISSUE=Venom {ECO:0000305};
RA   Kini M.R.;
RL   Submitted (AUG-1999) to UniProtKB.
CC   -!- FUNCTION: Blocks contraction of smooth muscle elicited by high
CC       potassium-induced depolarization, but does not block caffeine-
CC       stimulated contraction. May target voltage-gated calcium channels on
CC       smooth muscle (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- PTM: Contains 8 disulfide bonds. {ECO:0000250|UniProtKB:P84808}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR   AlphaFoldDB; P81993; -.
DR   SMR; P81993; -.
DR   PRIDE; P81993; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
PE   1: Evidence at protein level;
KW   Calcium channel impairing toxin; Direct protein sequencing; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Secreted; Toxin.
FT   CHAIN           1..>67
FT                   /note="Cysteine-rich venom protein bucarin"
FT                   /id="PRO_0000211529"
FT   DOMAIN          13..58
FT                   /note="SCP"
FT   NON_TER         67
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   67 AA;  7752 MW;  61D87DCA8A45B34E CRC64;
     ESSNKRENQK QIVDKHNALR RSVRPTARNM LQMEWNSNAA QNAKRFADRC TFAHSPPHLR
     TVGIFSC