ID   CRVP_HELAG              Reviewed;          21 AA.
AC   P0DJG8;
DT   16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2012, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Helicopsin;
DE   Flags: Fragments;
OS   Helicops angulatus (South American water snake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Dipsadidae; Helicops.
OX   NCBI_TaxID=121331;
RN   [1]
RP   PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION,
RP   SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND TOXIC DOSE.
RC   TISSUE=Saliva;
RX   PubMed=20931174; DOI=10.1007/s00204-010-0597-6;
RA   Estrella A., Sanchez E.E., Galan J.A., Tao W.A., Guerrero B.,
RA   Navarrete L.F., Rodriguez-Acosta A.;
RT   "Characterization of toxins from the broad-banded water snake Helicops
RT   angulatus (Linnaeus, 1758): isolation of a cysteine-rich secretory protein,
RT   Helicopsin.";
RL   Arch. Toxicol. 85:305-313(2011).
CC   -!- FUNCTION: Helicopsin exhibits robust neurotoxic activity as shown by
CC       immediate death (about 8 minutes) of mice due to respiratory paralysis.
CC       {ECO:0000269|PubMed:20931174}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20931174}.
CC   -!- TISSUE SPECIFICITY: Expressed by the salivary gland.
CC       {ECO:0000269|PubMed:20931174}.
CC   -!- PTM: Contains 8 disulfide bonds. {ECO:0000250}.
CC   -!- TOXIC DOSE: LD(50) is 5.3 mg/kg by intraperitoneal injection into mice.
CC       {ECO:0000269|PubMed:20931174}.
CC   -!- MISCELLANEOUS: Has no hemorrhagic activity.
CC       {ECO:0000305|PubMed:20931174}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR   AlphaFoldDB; P0DJG8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Neurotoxin; Secreted; Toxin.
FT   CHAIN           1..21
FT                   /note="Helicopsin"
FT                   /id="PRO_0000417009"
FT   NON_CONS        13..14
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT   NON_TER         21
SQ   SEQUENCE   21 AA;  2620 MW;  785B07D02212A4EB CRC64;
     MEWYPEAAAN AERYTQIVWY K