ID   CRVP_LATSE              Reviewed;         238 AA.
AC   Q8JI38;
DT   29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Cysteine-rich venom protein latisemin;
DE            Short=CRVP;
DE   Flags: Precursor;
OS   Laticauda semifasciata (Black-banded sea krait) (Pseudolaticauda
OS   semifasciata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Laticaudinae; Laticauda.
OX   NCBI_TaxID=8631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=12047379; DOI=10.1046/j.1432-1033.2002.02940.x;
RA   Yamazaki Y., Koike H., Sugiyama Y., Motoyoshi K., Wada T., Hishinuma S.,
RA   Mita M., Morita T.;
RT   "Cloning and characterization of novel snake venom proteins that block
RT   smooth muscle contraction.";
RL   Eur. J. Biochem. 269:2708-2715(2002).
CC   -!- FUNCTION: Blocks contraction of smooth muscle elicited by high
CC       potassium-induced depolarization (PubMed:12047379). May target voltage-
CC       gated calcium channels (Cav) on smooth muscle.
CC       {ECO:0000269|PubMed:12047379}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR   EMBL; AF384220; AAM45666.1; -; mRNA.
DR   AlphaFoldDB; Q8JI38; -.
DR   SMR; Q8JI38; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd05383; CAP_CRISP; 1.
DR   Gene3D; 1.10.10.740; -; 1.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR042076; Crisp-like_dom.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR013871; Cysteine_rich_secretory.
DR   InterPro; IPR034117; SCP_CRISP.
DR   InterPro; IPR003582; ShKT_dom.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   Pfam; PF08562; Crisp; 1.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
DR   PROSITE; PS01009; CRISP_1; 1.
DR   PROSITE; PS01010; CRISP_2; 1.
DR   PROSITE; PS51670; SHKT; 1.
PE   2: Evidence at transcript level;
KW   Calcium channel impairing toxin; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Secreted; Signal; Toxin;
KW   Voltage-gated calcium channel impairing toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000250"
FT   CHAIN           20..238
FT                   /note="Cysteine-rich venom protein latisemin"
FT                   /id="PRO_0000006278"
FT   DOMAIN          38..164
FT                   /note="SCP"
FT   DOMAIN          200..233
FT                   /note="ShKT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
FT   DISULFID        75..153
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
FT   DISULFID        92..165
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
FT   DISULFID        148..162
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
FT   DISULFID        184..191
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
FT   DISULFID        187..196
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
FT   DISULFID        200..233
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
FT   DISULFID        209..227
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
FT   DISULFID        218..231
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01005"
SQ   SEQUENCE   238 AA;  26416 MW;  2CBE6FFA231CA4CF CRC64;
     MIAFIVLLSL AAVLQQSSGT VDFASESSNK RENQKEIVDK HNALRRSVRP TARNMLQMEW
     NSDAAQNAQR WADRCSFAHS PSHLRTVGKF SCGENLFMSS QPYAWSRVIQ SWYDENKNFI
     YDVGANPPGS VIGHYTQIVW YKSHLLGCAA ARCSSSKYLY VCQYCPAGNI IGSIATPYKS
     GPPCGDCPSA CVNGLCTNPC KHENEFTNCQ SLVKQTGCQN TWIQSKCPAS CFCRTEII