CRVP_OVOOK
ID CRVP_OVOOK Reviewed; 30 AA.
AC P0DL18;
DT 01-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2013, sequence version 1.
DT 23-FEB-2022, entry version 16.
DE RecName: Full=Cysteine-rich venom protein okinavin;
DE Short=CRVP;
DE Flags: Fragment;
OS Ovophis okinavensis (Ryukyu Island pit viper) (Trimeresurus okinavensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Ovophis.
OX NCBI_TaxID=8769;
RN [1]
RP PROTEIN SEQUENCE.
RC TISSUE=Venom;
RX PubMed=19106157; DOI=10.1093/jb/mvn174;
RA Matsunaga Y., Yamazaki Y., Hyodo F., Sugiyama Y., Nozaki M., Morita T.;
RT "Structural divergence of cysteine-rich secretory proteins in snake
RT venoms.";
RL J. Biochem. 145:365-375(2009).
CC -!- FUNCTION: Inhibits calcium-activated potassium channels (KCa), voltage-
CC gated potassium channel (Kv), and the calcium release channel/ryanodine
CC receptor (RyR). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- PTM: Contains 8 disulfide bonds. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Calcium channel impairing toxin;
KW Calcium-activated potassium channel impairing toxin;
KW Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW Potassium channel impairing toxin;
KW Ryanodine-sensitive calcium-release channel impairing toxin; Secreted;
KW Toxin; Voltage-gated potassium channel impairing toxin.
FT CHAIN 1..>30
FT /note="Cysteine-rich venom protein okinavin"
FT /id="PRO_0000422148"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 30
SQ SEQUENCE 30 AA; 3498 MW; C1CDBC53F3EE9BC3 CRC64;
SVDFDSESPR KPXIQNEIVD LHNPLRRXVN