ID   CRVP_TITSE              Reviewed;         402 AA.
AC   A0A218QX58;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2017, sequence version 1.
DT   03-AUG-2022, entry version 8.
DE   RecName: Full=Cysteine-rich venom protein {ECO:0000305};
DE   AltName: Full=CRIVP {ECO:0000305};
DE   AltName: Full=Cysteine-rich protein {ECO:0000303|PubMed:31131005};
DE   Flags: Precursor;
OS   Tityus serrulatus (Brazilian scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
OX   NCBI_TaxID=6887;
RN   [1] {ECO:0000312|EMBL:JAW07031.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Telson;
RX   PubMed=29561852; DOI=10.1371/journal.pone.0193739;
RA   de Oliveira U.C., Nishiyama M.Y. Jr., Dos Santos M.B.V.,
RA   Santos-da-Silva A.P., Chalkidis H.M., Souza-Imberg A., Candido D.M.,
RA   Yamanouye N., Dorce V.A.C., Junqueira-de-Azevedo I.L.M.;
RT   "Proteomic endorsed transcriptomic profiles of venom glands from Tityus
RT   obscurus and T. serrulatus scorpions.";
RL   PLoS ONE 13:e0193739-e0193739(2018).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=31131005; DOI=10.1590/1678-9199-jvatitd-1482-18;
RA   Amorim F.G., Longhim H.T., Cologna C.T., Degueldre M., Pauw E., Quinton L.,
RA   Arantes E.C.;
RT   "Proteome of fraction from Tityus serrulatus venom reveals new enzymes and
RT   toxins.";
RL   J. Venom. Anim. Toxins Incl. Trop. Dis. 25:e148218-e148218(2019).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:31131005}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- PTM: Contains 7 disulfide bonds. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR   EMBL; GEUW01000014; JAW07031.1; -; Transcribed_RNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR002413; V5_allergen-like.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00838; V5ALLERGEN.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
DR   PROSITE; PS01009; CRISP_1; 1.
DR   PROSITE; PS01010; CRISP_2; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..13
FT                   /evidence="ECO:0000305|PubMed:31131005"
FT   CHAIN           14..402
FT                   /note="Cysteine-rich venom protein"
FT                   /evidence="ECO:0000305|PubMed:31131005"
FT                   /id="PRO_5012849536"
FT   DOMAIN          57..199
FT                   /note="SCP"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   402 AA;  44870 MW;  C7D1279969149C02 CRC64;
     MNLALFIIFA TIFENVVPEN CPKMYRRLSK SHTFCTPSTC KIEAGGKVTE SDKQTILETH
     NQLRNKLATG KENQYQKLSS AANMMQMEWD DELAAVAQAH ANQCKFEHDS GDQRAVGNFS
     VGQNLLETSG IFSIDWGKVK IWYTTEVDDF YPEYNKPFQF HGSYGHFSQV IWAKTWKVGC
     GVAGYVENGV KKVLYTCNYG PAGNLVGSEA YQVGSPCSAC PENTKCSATY PGLCKSITPD
     GPQIRRPSSK DYLLYCDFSD KDPKACKDVT MTGSRPFTTQ KLYTGKYVTQ VFNAGENMTI
     NFGKFEHKGG LCAFLIGRFG PNVAGETAAS EVNFHFSAPH LIFPEGMKET RPITSWHTIG
     ILMRWDKELQ ISYVFKVKPP TAKPPPQYFE FKEYGVKGGS CP