ID   CRVP_TROCA              Reviewed;          27 AA.
AC   P81994;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2004, sequence version 1.
DT   23-FEB-2022, entry version 40.
DE   RecName: Full=Cysteine-rich venom protein tropirin;
DE            Short=CRVP;
DE   Flags: Fragment;
OS   Tropidechis carinatus (Australian rough-scaled snake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Notechinae; Tropidechis.
OX   NCBI_TaxID=100989;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Venom;
RA   Kini M.R.;
RL   Submitted (AUG-1999) to UniProtKB.
CC   -!- FUNCTION: Blocks contraction of smooth muscle elicited by high
CC       potassium-induced depolarization, but does not block caffeine-
CC       stimulated contraction. May target voltage-gated calcium channels on
CC       smooth muscle (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- PTM: Contains 8 disulfide bonds. {ECO:0000250|UniProtKB:P84808}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Calcium channel impairing toxin; Direct protein sequencing; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Secreted; Toxin.
FT   CHAIN           1..>27
FT                   /note="Cysteine-rich venom protein tropirin"
FT                   /id="PRO_0000211531"
FT   NON_TER         27
SQ   SEQUENCE   27 AA;  3075 MW;  314C454481CE381D CRC64;
     GGGKDYRVEI VDKHNXLRRS VXXTARN