ID   CRX_BOVIN               Reviewed;         299 AA.
AC   Q9XSK0;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=Cone-rod homeobox protein;
GN   Name=CRX;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RA   Zhu X., Craft C.M.;
RT   "Interaction of phosducin and PhLOP1 with CRX: potential transcriptional
RT   regulation function.";
RL   Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that binds and transactivates the
CC       sequence 5'-TAATC[CA]-3' which is found upstream of several
CC       photoreceptor-specific genes, including the opsin genes. Acts
CC       synergistically with other transcription factors, such as NRL, RORB and
CC       RAX, to regulate photoreceptor cell-specific gene transcription.
CC       Essential for the maintenance of mammalian photoreceptors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts (via the homeobox) with NRL (via the leucine-zipper
CC       domain). Interacts with PDC, RAX2, RORB and SCA7 (By similarity).
CC       {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q9XSK0; P54845: NRL; Xeno; NbExp=6; IntAct=EBI-8843794, EBI-8843813;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Retina.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR   EMBL; AF154123; AAD34645.1; -; mRNA.
DR   RefSeq; NP_776329.1; NM_173904.2.
DR   AlphaFoldDB; Q9XSK0; -.
DR   SMR; Q9XSK0; -.
DR   BioGRID; 158156; 1.
DR   IntAct; Q9XSK0; 2.
DR   STRING; 9913.ENSBTAP00000028232; -.
DR   PaxDb; Q9XSK0; -.
DR   PRIDE; Q9XSK0; -.
DR   GeneID; 280756; -.
DR   KEGG; bta:280756; -.
DR   CTD; 1406; -.
DR   eggNOG; KOG2251; Eukaryota.
DR   HOGENOM; CLU_064370_0_0_1; -.
DR   InParanoid; Q9XSK0; -.
DR   OrthoDB; 1481439at2759; -.
DR   TreeFam; TF351179; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0000785; C:chromatin; IDA:ARUK-UCL.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IDA:ARUK-UCL.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IDA:ARUK-UCL.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0016922; F:nuclear receptor binding; ISS:UniProtKB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IPI:ARUK-UCL.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:ARUK-UCL.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR013851; Otx_TF_C.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03529; TF_Otx; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   Activator; Developmental protein; Differentiation; DNA-binding; Homeobox;
KW   Neurogenesis; Nucleus; Reference proteome; Sensory transduction;
KW   Transcription; Transcription regulation; Vision.
FT   CHAIN           1..299
FT                   /note="Cone-rod homeobox protein"
FT                   /id="PRO_0000048860"
FT   DNA_BIND        39..98
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          94..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          236..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        240..258
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   299 AA;  32253 MW;  512ED6A6DAFBAC19 CRC64;
     MMAYMNPGPH YSVNALALSG PSVDLMHPAV SYPSAPRKQR RERTTFTRSQ LEELEALFAK
     TQYPDVYARE EVALKINLPE SRVQVWFKNR RAKCRQQRQQ QKQQQQPPGA QAKARPAKRK
     AGTSPRSSTD VCPDPLGISD SYSPPLPGPS GSPTTAVATV SIWSPASESP LPEAQRAGLV
     ASGPSLTSAP YAMTYAPASA FCSSPSAYGS PSSYFSGLDP YLSPMVPPLG GPALSPLSGP
     SVGPSLTQSP TSLSGQSYGT YSPVDSLEFK DPTGTWKFTY NPMDPLDYKD QSAWKFQIL