ID   CRX_CANLF               Reviewed;         299 AA.
AC   Q8SQ03;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Cone-rod homeobox protein;
GN   Name=CRX;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11951083;
RA   Akhmedov N.B., Baldwin V.J., Zangerl B., Kijas J.W., Hunter L.,
RA   Minoofar K.D., Mellersh C., Ostrander E.A., Acland G.M., Farber D.B.,
RA   Aguirre G.D.;
RT   "Cloning and characterization of the canine photoreceptor specific cone-rod
RT   homeobox (CRX) gene and evaluation as a candidate for early onset
RT   photoreceptor diseases in the dog.";
RL   Mol. Vis. 8:79-84(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Dekomien G., Epplen J.T.;
RT   "Characterization of the canine CRX gene.";
RL   Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that binds and transactivates the
CC       sequence 5'-TAATC[CA]-3' which is found upstream of several
CC       photoreceptor-specific genes, including the opsin genes. Acts
CC       synergistically with other transcription factors, such as NRL, RORB and
CC       RAX, to regulate photoreceptor cell-specific gene transcription.
CC       Essential for the maintenance of mammalian photoreceptors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts (via the homeobox) with NRL (via the leucine-zipper
CC       domain). Interacts with PDC, RAX2, RORB and SCA7 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Retina.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR   EMBL; AF454668; AAL91721.1; -; mRNA.
DR   EMBL; AJ507727; CAD45642.1; -; Genomic_DNA.
DR   EMBL; AJ507728; CAD45642.1; JOINED; Genomic_DNA.
DR   EMBL; AJ507729; CAD45642.1; JOINED; Genomic_DNA.
DR   RefSeq; NP_001003049.1; NM_001003049.1.
DR   AlphaFoldDB; Q8SQ03; -.
DR   SMR; Q8SQ03; -.
DR   STRING; 9612.ENSCAFP00000006035; -.
DR   PaxDb; Q8SQ03; -.
DR   GeneID; 403577; -.
DR   KEGG; cfa:403577; -.
DR   CTD; 1406; -.
DR   eggNOG; KOG2251; Eukaryota.
DR   InParanoid; Q8SQ03; -.
DR   OrthoDB; 1481439at2759; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0016922; F:nuclear receptor binding; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR013851; Otx_TF_C.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03529; TF_Otx; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; Differentiation; DNA-binding; Homeobox;
KW   Neurogenesis; Nucleus; Reference proteome; Sensory transduction;
KW   Transcription; Transcription regulation; Vision.
FT   CHAIN           1..299
FT                   /note="Cone-rod homeobox protein"
FT                   /id="PRO_0000048861"
FT   DNA_BIND        39..98
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          92..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          236..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        241..257
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   299 AA;  32343 MW;  1896D2B9E72FF08A CRC64;
     MMAYMNPGPH YSVNALALSG PSVDLMHQAV SYPSAPRKQR RERTTFTRSQ LEELEALFAK
     TQYPDVYARE EVALKINLPE SRVQVWFKNR RAKCRQQRQQ QKEQPQPPGA QTKARPAKRK
     AGMSPRSSSD VCPDPLGISD SYSPPLLGPS GSPTTAVATV SIWSPASESP LPEAQRGGLV
     ASGPPLTSTP YAMTYAPASA FCSSPSAYGS PSSYFSGLDP YLSPMVPQLG GPALSPLSGP
     SVGPSLAQSP TSLSGQSYGT YSPVDSLEFK DPTGTWKFTY NPMDPLDYKD QSAWKFQIL