CRYD_GIBZE
ID CRYD_GIBZE Reviewed; 697 AA.
AC Q4I1Q6; A0A098DEC3; A0A0E0S1C4; V6RR81;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-SEP-2016, sequence version 2.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Putative cryptochrome DASH;
GN ORFNames=FGRRES_16955, FGSG_08852;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
CC -!- FUNCTION: May have a photoreceptor function. {ECO:0000250}.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC Note=Binds 1 FAD per subunit. {ECO:0000250};
CC -!- COFACTOR:
CC Name=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate;
CC Xref=ChEBI:CHEBI:15636; Evidence={ECO:0000250};
CC Note=Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.
CC {ECO:0000250};
CC -!- SIMILARITY: Belongs to the DNA photolyase class-1 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ESU14435.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; DS231667; ESU14435.1; ALT_SEQ; Genomic_DNA.
DR EMBL; HG970333; CEF77299.1; -; Genomic_DNA.
DR RefSeq; XP_011319860.1; XM_011321558.1.
DR AlphaFoldDB; Q4I1Q6; -.
DR SMR; Q4I1Q6; -.
DR STRING; 5518.FGSG_08852P0; -.
DR EnsemblFungi; ESU14435; ESU14435; FGSG_08852.
DR GeneID; 23555834; -.
DR KEGG; fgr:FGSG_08852; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G10993; -.
DR eggNOG; KOG0133; Eukaryota.
DR HOGENOM; CLU_010348_6_1_1; -.
DR InParanoid; Q4I1Q6; -.
DR Proteomes; UP000070720; Chromosome 2.
DR GO; GO:0003913; F:DNA photolyase activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR Gene3D; 3.40.50.620; -; 1.
DR InterPro; IPR014133; Cry_DASH.
DR InterPro; IPR036134; Crypto/Photolyase_FAD-like_sf.
DR InterPro; IPR036155; Crypto/Photolyase_N_sf.
DR InterPro; IPR005101; Cryptochr/Photolyase_FAD-bd.
DR InterPro; IPR002081; Cryptochrome/DNA_photolyase_1.
DR InterPro; IPR006050; DNA_photolyase_N.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR PANTHER; PTHR11455; PTHR11455; 1.
DR Pfam; PF00875; DNA_photolyase; 1.
DR Pfam; PF03441; FAD_binding_7; 1.
DR PRINTS; PR00147; DNAPHOTLYASE.
DR SUPFAM; SSF48173; SSF48173; 1.
DR SUPFAM; SSF52425; SSF52425; 1.
DR TIGRFAMs; TIGR02765; crypto_DASH; 1.
DR PROSITE; PS51645; PHR_CRY_ALPHA_BETA; 1.
PE 3: Inferred from homology;
KW Chromophore; FAD; Flavoprotein; Reference proteome.
FT CHAIN 1..697
FT /note="Putative cryptochrome DASH"
FT /id="PRO_0000235323"
FT DOMAIN 5..164
FT /note="Photolyase/cryptochrome alpha/beta"
FT REGION 170..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..577
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 697 AA; 79863 MW; AA66F58296577C17 CRC64;
MAGNKLLVYL LRRDLRATDN PILHHLATSD HGFTHLLPIY ILPPHQIETS GFVVEGQKSP
YPLAKSQVGR FWRCGPLRAK FQAECIWDVK KNFENIGSGM LIRIGKFDDV LKHLIKSLNE
DHQSIDTVWM TEEPSKEELD DQTAVASVCS KEGIGFKLWH DEKYFIDDRD NGLKDPQDTP
DVFTTYRKTQ EPLRERPRPP LPRPQAGSLP SFPSWIPPQQ APFRIPDDYD EFERLLLEPV
KAPIISDPPQ FPEGAKSAHP FKGGETPAWD RLYHLIKSGA MTTYQETRNG LLGTEYSTKL
SAFLAMGTIT ARSIHAELVK FEDGSEESYS RGFGFGKGEN EGTRAVRFEL LWRDYMRLCT
FKFRTRLFKI DGFKGASGNY TKKWLTDREE DAEPDQNPTP AQVKDMIDRW IRGTTGMGLV
DASQRELQLT GYTSNRARQN VASYLTKSLG IDWRLGAEYY EQSLIDYDTH SNWGNWQYQA
SCGNDPRSRS FNQVKQAFDY DQDGRFTRTW VNEVKSIDRL EHVFQICTCP KQELEKHGLS
DNIMVTNPLK RIDFSVTKPR GNRRPYRWRK QGDRGRGGRG GRGGGTGNTS GNGDNRHNEP
SPPNGGNRHN DFSPANGGSY MQGQPISGGY QQMAWRGNSH GLPSGRGYNS RQYMLDYSQQ
QQQPQHQLQH YYAHQQHQHP HPRQQQQQFY HQIPPHI
