ID   CRYD_GLOVI              Reviewed;         500 AA.
AC   Q7NMD1;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Cryptochrome DASH;
GN   Name=cry; Synonyms=phrA; OrderedLocusNames=glr0835;
OS   Gloeobacter violaceus (strain ATCC 29082 / PCC 7421).
OC   Bacteria; Cyanobacteria; Gloeobacteria; Gloeobacterales; Gloeobacteraceae;
OC   Gloeobacter.
OX   NCBI_TaxID=251221;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29082 / PCC 7421;
RX   PubMed=14621292; DOI=10.1093/dnares/10.4.137;
RA   Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T.,
RA   Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M.,
RA   Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M.,
RA   Tabata S.;
RT   "Complete genome structure of Gloeobacter violaceus PCC 7421, a
RT   cyanobacterium that lacks thylakoids.";
RL   DNA Res. 10:137-145(2003).
CC   -!- FUNCTION: May have a photoreceptor function. Binds DNA; probably
CC       functions as a transcriptional repressor (By similarity).
CC       {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC       Note=Binds 1 FAD per subunit. {ECO:0000250};
CC   -!- COFACTOR:
CC       Name=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate;
CC         Xref=ChEBI:CHEBI:15636; Evidence={ECO:0000250};
CC       Note=Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.
CC       {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the DNA photolyase class-1 family.
CC       {ECO:0000305}.
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DR   EMBL; BA000045; BAC88776.1; -; Genomic_DNA.
DR   RefSeq; NP_923781.1; NC_005125.1.
DR   RefSeq; WP_011140837.1; NC_005125.1.
DR   AlphaFoldDB; Q7NMD1; -.
DR   SMR; Q7NMD1; -.
DR   STRING; 251221.35211397; -.
DR   EnsemblBacteria; BAC88776; BAC88776; BAC88776.
DR   KEGG; gvi:glr0835; -.
DR   PATRIC; fig|251221.4.peg.853; -.
DR   eggNOG; COG0415; Bacteria.
DR   HOGENOM; CLU_010348_6_2_3; -.
DR   InParanoid; Q7NMD1; -.
DR   OMA; NWNYTAG; -.
DR   OrthoDB; 184000at2; -.
DR   PhylomeDB; Q7NMD1; -.
DR   Proteomes; UP000000557; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0003913; F:DNA photolyase activity; IEA:InterPro.
DR   GO; GO:0071949; F:FAD binding; IBA:GO_Central.
DR   GO; GO:0000719; P:photoreactive repair; IBA:GO_Central.
DR   Gene3D; 3.40.50.620; -; 1.
DR   InterPro; IPR014133; Cry_DASH.
DR   InterPro; IPR036134; Crypto/Photolyase_FAD-like_sf.
DR   InterPro; IPR036155; Crypto/Photolyase_N_sf.
DR   InterPro; IPR005101; Cryptochr/Photolyase_FAD-bd.
DR   InterPro; IPR002081; Cryptochrome/DNA_photolyase_1.
DR   InterPro; IPR018394; DNA_photolyase_1_CS_C.
DR   InterPro; IPR006050; DNA_photolyase_N.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR11455; PTHR11455; 1.
DR   Pfam; PF00875; DNA_photolyase; 1.
DR   Pfam; PF03441; FAD_binding_7; 1.
DR   PRINTS; PR00147; DNAPHOTLYASE.
DR   SUPFAM; SSF48173; SSF48173; 1.
DR   SUPFAM; SSF52425; SSF52425; 1.
DR   TIGRFAMs; TIGR02765; crypto_DASH; 1.
DR   PROSITE; PS00394; DNA_PHOTOLYASES_1_1; 1.
DR   PROSITE; PS51645; PHR_CRY_ALPHA_BETA; 1.
PE   3: Inferred from homology;
KW   Chromophore; DNA-binding; FAD; Flavoprotein; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..500
FT                   /note="Cryptochrome DASH"
FT                   /id="PRO_0000235308"
FT   DOMAIN          4..138
FT                   /note="Photolyase/cryptochrome alpha/beta"
SQ   SEQUENCE   500 AA;  57263 MW;  622C7BAACD7ACAC5 CRC64;
     MSTKTVLVWY RNDLRVHDHE PLTSALHKNA RVVALYCFDP RQFGKAPFGF EKTGPFRARF
     LLESVADLRR SLRQLGSDLL VRRGHPEEVI PALVSELEIA AVHYHGEVTS EELVVERDLQ
     AALAPLNVPV RSFWGTTLVH PDDLPFAIEA IPELFTDFRK QVERSAAINP PLPAPAKLPP
     LPAVDPGEIP QLADLGLESP VTDERAVLQF KGGETSGLAR LEEYFWQKSL LKSYKQTRNG
     MLGADYSSKF SAWLALGCLS ARYIHEQVQT YETKRIKNDS TYWLIFELLW RDYFRFIAAK
     HGDRLFYTAG LRGLDIPWKE DWERFELWRT GQTGFPLVDA NMRELAATGF MSNRGRQNVA
     SFLTKNLGIH WHMGAEWFES RLIDYDVASN WGNWNYTAGV GNDARGFRFF NILKQARDYD
     PDGAYVKHWL PELAGLPPAR VHEPWKLLPV EQKRFGVRLG VDYPQPVVDL FQSAAANEAI
     YNAAWEHHHR KRRGQPRSRT