ID   CRYD_IDILO              Reviewed;         449 AA.
AC   Q5QXE0;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Cryptochrome DASH;
GN   Name=cry; Synonyms=phrB2; OrderedLocusNames=IL0122;
OS   Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Idiomarinaceae; Idiomarina.
OX   NCBI_TaxID=283942;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-735 / DSM 15497 / L2-TR;
RX   PubMed=15596722; DOI=10.1073/pnas.0407638102;
RA   Hou S., Saw J.H., Lee K.S., Freitas T.A., Belisle C., Kawarabayasi Y.,
RA   Donachie S.P., Pikina A., Galperin M.Y., Koonin E.V., Makarova K.S.,
RA   Omelchenko M.V., Sorokin A., Wolf Y.I., Li Q.X., Keum Y.S., Campbell S.,
RA   Denery J., Aizawa S., Shibata S., Malahoff A., Alam M.;
RT   "Genome sequence of the deep-sea gamma-proteobacterium Idiomarina
RT   loihiensis reveals amino acid fermentation as a source of carbon and
RT   energy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:18036-18041(2004).
CC   -!- FUNCTION: May have a photoreceptor function. Binds DNA; probably
CC       functions as a transcriptional repressor (By similarity).
CC       {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC       Note=Binds 1 FAD per subunit. {ECO:0000250};
CC   -!- COFACTOR:
CC       Name=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate;
CC         Xref=ChEBI:CHEBI:15636; Evidence={ECO:0000250};
CC       Note=Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.
CC       {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the DNA photolyase class-1 family.
CC       {ECO:0000305}.
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DR   EMBL; AE017340; AAV80965.1; -; Genomic_DNA.
DR   RefSeq; WP_011233385.1; NC_006512.1.
DR   AlphaFoldDB; Q5QXE0; -.
DR   SMR; Q5QXE0; -.
DR   STRING; 283942.IL0122; -.
DR   EnsemblBacteria; AAV80965; AAV80965; IL0122.
DR   KEGG; ilo:IL0122; -.
DR   eggNOG; COG0415; Bacteria.
DR   HOGENOM; CLU_010348_6_2_6; -.
DR   OMA; NWNYTAG; -.
DR   OrthoDB; 184000at2; -.
DR   Proteomes; UP000001171; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003913; F:DNA photolyase activity; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   Gene3D; 3.40.50.620; -; 1.
DR   InterPro; IPR014133; Cry_DASH.
DR   InterPro; IPR036134; Crypto/Photolyase_FAD-like_sf.
DR   InterPro; IPR036155; Crypto/Photolyase_N_sf.
DR   InterPro; IPR005101; Cryptochr/Photolyase_FAD-bd.
DR   InterPro; IPR002081; Cryptochrome/DNA_photolyase_1.
DR   InterPro; IPR006050; DNA_photolyase_N.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR11455; PTHR11455; 1.
DR   Pfam; PF00875; DNA_photolyase; 1.
DR   Pfam; PF03441; FAD_binding_7; 1.
DR   PRINTS; PR00147; DNAPHOTLYASE.
DR   SUPFAM; SSF48173; SSF48173; 1.
DR   SUPFAM; SSF52425; SSF52425; 1.
DR   TIGRFAMs; TIGR02765; crypto_DASH; 1.
DR   PROSITE; PS51645; PHR_CRY_ALPHA_BETA; 1.
PE   3: Inferred from homology;
KW   Chromophore; DNA-binding; FAD; Flavoprotein; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..449
FT                   /note="Cryptochrome DASH"
FT                   /id="PRO_0000235309"
FT   DOMAIN          15..147
FT                   /note="Photolyase/cryptochrome alpha/beta"
SQ   SEQUENCE   449 AA;  51933 MW;  C5732C8FB626B921 CRC64;
     MNTKQQLVFI MADYRLGLFV FRNDLRVEDN LALYEAAQRS ETLICCFCFN PTQNKYGHYG
     IPAMGKHRFT FLQQSLKQLR TELEMRGQKL IVLTGTFDRI LTELISERQV DAIFLSQHQG
     YYERLQLGLL QQRFPFLPFH ETPNNTLFSE QELPFELADL PETFSQFRKK VEPLSRNFSV
     QPVNALPSLP KNISYPGFKA ETLNELASDD FEGGERAALT HLTSYFSGES AGTYKQTRNA
     LDDFSSSTKF SPWLAQGCLS VRQIMAALRA YETEFGENES SYWISFELLW REYFFWYALK
     HGKRLFAFSG LSGKSPKTSF YSERFQKWCS GNTPYPIVNA CMKQLNATGY MSNRGRQLVA
     SCFVHELSLD WRYGAAYFEQ QLIDYDVSSN WGNWQYLAGV GADPRGHRQF NLEKQTERYD
     PDNEFIERWA GDLSGQPIDS VDAADWPVR