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CRYD_NATPD
ID   CRYD_NATPD              Reviewed;         474 AA.
AC   Q3IPX9;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Cryptochrome DASH;
GN   Name=cry; Synonyms=phr2; OrderedLocusNames=NP_3456A;
OS   Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM
OS   8858 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Natronomonas.
OX   NCBI_TaxID=348780;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB
RC   2260 / Gabara;
RX   PubMed=16169924; DOI=10.1101/gr.3952905;
RA   Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J.,
RA   Oesterhelt D.;
RT   "Living with two extremes: conclusions from the genome sequence of
RT   Natronomonas pharaonis.";
RL   Genome Res. 15:1336-1343(2005).
CC   -!- FUNCTION: May have a photoreceptor function. Binds DNA; probably
CC       functions as a transcriptional repressor (By similarity).
CC       {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC       Note=Binds 1 FAD per subunit. {ECO:0000250};
CC   -!- COFACTOR:
CC       Name=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate;
CC         Xref=ChEBI:CHEBI:15636; Evidence={ECO:0000250};
CC       Note=Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.
CC       {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the DNA photolyase class-1 family.
CC       {ECO:0000305}.
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DR   EMBL; CR936257; CAI49819.1; -; Genomic_DNA.
DR   RefSeq; WP_011323439.1; NC_007426.1.
DR   AlphaFoldDB; Q3IPX9; -.
DR   SMR; Q3IPX9; -.
DR   STRING; 348780.NP_3456A; -.
DR   PRIDE; Q3IPX9; -.
DR   EnsemblBacteria; CAI49819; CAI49819; NP_3456A.
DR   GeneID; 3703032; -.
DR   KEGG; nph:NP_3456A; -.
DR   eggNOG; arCOG02840; Archaea.
DR   HOGENOM; CLU_010348_6_2_2; -.
DR   OMA; NWNYTAG; -.
DR   OrthoDB; 21461at2157; -.
DR   Proteomes; UP000002698; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003913; F:DNA photolyase activity; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   Gene3D; 3.40.50.620; -; 1.
DR   InterPro; IPR014133; Cry_DASH.
DR   InterPro; IPR036134; Crypto/Photolyase_FAD-like_sf.
DR   InterPro; IPR036155; Crypto/Photolyase_N_sf.
DR   InterPro; IPR005101; Cryptochr/Photolyase_FAD-bd.
DR   InterPro; IPR002081; Cryptochrome/DNA_photolyase_1.
DR   InterPro; IPR006050; DNA_photolyase_N.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR11455; PTHR11455; 1.
DR   Pfam; PF00875; DNA_photolyase; 1.
DR   Pfam; PF03441; FAD_binding_7; 1.
DR   PRINTS; PR00147; DNAPHOTLYASE.
DR   SUPFAM; SSF48173; SSF48173; 1.
DR   SUPFAM; SSF52425; SSF52425; 1.
DR   TIGRFAMs; TIGR02765; crypto_DASH; 1.
DR   PROSITE; PS51645; PHR_CRY_ALPHA_BETA; 1.
PE   3: Inferred from homology;
KW   Chromophore; DNA-binding; FAD; Flavoprotein; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..474
FT                   /note="Cryptochrome DASH"
FT                   /id="PRO_0000235315"
FT   DOMAIN          2..136
FT                   /note="Photolyase/cryptochrome alpha/beta"
FT   REGION          161..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   474 AA;  53666 MW;  9CEB7D792AED04F5 CRC64;
     MDTAVVWFRD DLRVTDNPTL ADAVAAAETV IPVYTFDPDR YTESEYGPPK TGGHRAVFRR
     QAVADLRASL RDRGGDLLVR SGRPATVVPE LAQRAGADAV YAQTKPATEE RRRAADVASA
     LDDAGIALRQ RWTHTLYHPD DLPTPPTDID DTFTPWRKET EAAATVRDPR SAPETVPTPD
     GLTPGPVPTV ESLGVSEPPT DDRAVLEFEG GESAGKRRVE SYIWEGDHLR EYKTTRNGLL
     GADYSSKFSP WLAAGCLSPR WLHREVERYE DERVANEDTY WLVFELAWRD FFQFQFEKYG
     ATFFKPGGIR ERNIDWDRDR ALFERWADGE TGVPFVDANM RELNRTGYMS NRGRQNVASF
     LAGVLGIDWR WGAAYFEARL IDYDVASNWG NWAYQAGVGN DSRDRYFDVR SQAERYDSDA
     EYITTWLPEL AALPATIAHQ PWQLSEAEQR EYGVELGVDY PEPVVDIDAR YQSL
 
 
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