CRYD_NATPD
ID CRYD_NATPD Reviewed; 474 AA.
AC Q3IPX9;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Cryptochrome DASH;
GN Name=cry; Synonyms=phr2; OrderedLocusNames=NP_3456A;
OS Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM
OS 8858 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Natronomonas.
OX NCBI_TaxID=348780;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB
RC 2260 / Gabara;
RX PubMed=16169924; DOI=10.1101/gr.3952905;
RA Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J.,
RA Oesterhelt D.;
RT "Living with two extremes: conclusions from the genome sequence of
RT Natronomonas pharaonis.";
RL Genome Res. 15:1336-1343(2005).
CC -!- FUNCTION: May have a photoreceptor function. Binds DNA; probably
CC functions as a transcriptional repressor (By similarity).
CC {ECO:0000250}.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC Note=Binds 1 FAD per subunit. {ECO:0000250};
CC -!- COFACTOR:
CC Name=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate;
CC Xref=ChEBI:CHEBI:15636; Evidence={ECO:0000250};
CC Note=Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.
CC {ECO:0000250};
CC -!- SIMILARITY: Belongs to the DNA photolyase class-1 family.
CC {ECO:0000305}.
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DR EMBL; CR936257; CAI49819.1; -; Genomic_DNA.
DR RefSeq; WP_011323439.1; NC_007426.1.
DR AlphaFoldDB; Q3IPX9; -.
DR SMR; Q3IPX9; -.
DR STRING; 348780.NP_3456A; -.
DR PRIDE; Q3IPX9; -.
DR EnsemblBacteria; CAI49819; CAI49819; NP_3456A.
DR GeneID; 3703032; -.
DR KEGG; nph:NP_3456A; -.
DR eggNOG; arCOG02840; Archaea.
DR HOGENOM; CLU_010348_6_2_2; -.
DR OMA; NWNYTAG; -.
DR OrthoDB; 21461at2157; -.
DR Proteomes; UP000002698; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003913; F:DNA photolyase activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR Gene3D; 3.40.50.620; -; 1.
DR InterPro; IPR014133; Cry_DASH.
DR InterPro; IPR036134; Crypto/Photolyase_FAD-like_sf.
DR InterPro; IPR036155; Crypto/Photolyase_N_sf.
DR InterPro; IPR005101; Cryptochr/Photolyase_FAD-bd.
DR InterPro; IPR002081; Cryptochrome/DNA_photolyase_1.
DR InterPro; IPR006050; DNA_photolyase_N.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR PANTHER; PTHR11455; PTHR11455; 1.
DR Pfam; PF00875; DNA_photolyase; 1.
DR Pfam; PF03441; FAD_binding_7; 1.
DR PRINTS; PR00147; DNAPHOTLYASE.
DR SUPFAM; SSF48173; SSF48173; 1.
DR SUPFAM; SSF52425; SSF52425; 1.
DR TIGRFAMs; TIGR02765; crypto_DASH; 1.
DR PROSITE; PS51645; PHR_CRY_ALPHA_BETA; 1.
PE 3: Inferred from homology;
KW Chromophore; DNA-binding; FAD; Flavoprotein; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..474
FT /note="Cryptochrome DASH"
FT /id="PRO_0000235315"
FT DOMAIN 2..136
FT /note="Photolyase/cryptochrome alpha/beta"
FT REGION 161..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 474 AA; 53666 MW; 9CEB7D792AED04F5 CRC64;
MDTAVVWFRD DLRVTDNPTL ADAVAAAETV IPVYTFDPDR YTESEYGPPK TGGHRAVFRR
QAVADLRASL RDRGGDLLVR SGRPATVVPE LAQRAGADAV YAQTKPATEE RRRAADVASA
LDDAGIALRQ RWTHTLYHPD DLPTPPTDID DTFTPWRKET EAAATVRDPR SAPETVPTPD
GLTPGPVPTV ESLGVSEPPT DDRAVLEFEG GESAGKRRVE SYIWEGDHLR EYKTTRNGLL
GADYSSKFSP WLAAGCLSPR WLHREVERYE DERVANEDTY WLVFELAWRD FFQFQFEKYG
ATFFKPGGIR ERNIDWDRDR ALFERWADGE TGVPFVDANM RELNRTGYMS NRGRQNVASF
LAGVLGIDWR WGAAYFEARL IDYDVASNWG NWAYQAGVGN DSRDRYFDVR SQAERYDSDA
EYITTWLPEL AALPATIAHQ PWQLSEAEQR EYGVELGVDY PEPVVDIDAR YQSL