CRYD_NEUCR
ID CRYD_NEUCR Reviewed; 745 AA.
AC Q7SI68;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Putative cryptochrome DASH, mitochondrial;
DE Flags: Precursor;
GN Name=cry; ORFNames=B22I21.260, NCU00582;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: May have a photoreceptor function. {ECO:0000250}.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC Note=Binds 1 FAD per subunit. {ECO:0000250};
CC -!- COFACTOR:
CC Name=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate;
CC Xref=ChEBI:CHEBI:15636; Evidence={ECO:0000250};
CC Note=Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.
CC {ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the DNA photolyase class-1 family.
CC {ECO:0000305}.
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DR EMBL; BX842641; CAE76612.1; -; Genomic_DNA.
DR EMBL; CM002236; EAA36486.3; -; Genomic_DNA.
DR RefSeq; XP_965722.3; XM_960629.3.
DR AlphaFoldDB; Q7SI68; -.
DR SMR; Q7SI68; -.
DR STRING; 5141.EFNCRP00000000625; -.
DR EnsemblFungi; EAA36486; EAA36486; NCU00582.
DR GeneID; 3881951; -.
DR KEGG; ncr:NCU00582; -.
DR VEuPathDB; FungiDB:NCU00582; -.
DR HOGENOM; CLU_010348_6_1_1; -.
DR InParanoid; Q7SI68; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IBA:GO_Central.
DR GO; GO:0003904; F:deoxyribodipyrimidine photo-lyase activity; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0071949; F:FAD binding; IBA:GO_Central.
DR GO; GO:0000719; P:photoreactive repair; IBA:GO_Central.
DR Gene3D; 3.40.50.620; -; 1.
DR InterPro; IPR014133; Cry_DASH.
DR InterPro; IPR036134; Crypto/Photolyase_FAD-like_sf.
DR InterPro; IPR036155; Crypto/Photolyase_N_sf.
DR InterPro; IPR005101; Cryptochr/Photolyase_FAD-bd.
DR InterPro; IPR002081; Cryptochrome/DNA_photolyase_1.
DR InterPro; IPR006050; DNA_photolyase_N.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR PANTHER; PTHR11455; PTHR11455; 1.
DR Pfam; PF00875; DNA_photolyase; 1.
DR Pfam; PF03441; FAD_binding_7; 1.
DR PRINTS; PR00147; DNAPHOTLYASE.
DR SUPFAM; SSF48173; SSF48173; 1.
DR SUPFAM; SSF52425; SSF52425; 1.
DR TIGRFAMs; TIGR02765; crypto_DASH; 1.
DR PROSITE; PS51645; PHR_CRY_ALPHA_BETA; 1.
PE 3: Inferred from homology;
KW Chromophore; FAD; Flavoprotein; Mitochondrion; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..22
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 23..745
FT /note="Putative cryptochrome DASH, mitochondrial"
FT /id="PRO_0000235322"
FT DOMAIN 23..166
FT /note="Photolyase/cryptochrome alpha/beta"
FT REGION 563..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 745 AA; 81412 MW; 44BA30079BE86723 CRC64;
MAPSKVVIYA MRRELRLSDN PIFHHLSNPE SKHGFSHLLP VYVFPAQQID LSGFVPKGSE
NPHPAPKSAV GGYARCGPYR AKFLAESVWD LKTSLQSIGS DLLVRAGPYK DVIQSLVEGL
KAKECQVGAV WMTSHEGSEE KSEEKTVASF CAKSGIDFKL WDDEKYLIHD RDTGITHLND
LPDVFTTYRK QIEPLREKAR KTLPVPEKGA LPAYPDIDMI PSQQPPFNIP GTCEELVDAV
VRPVKNFLKD LPDFPEKAES SHPFRGGETS AHKRIDHLVL SGGMKSYKDS RNGLLGPDFS
TKLSAYLAQG CVTARQIHHA LVAYEDGTGT KYKGADGFGE GDNQGTETVR MELLWRDYMR
LCHQKYGDKL FRVEGFNGKH TDYEGEDKKY GWRTANTSIA LPGQEPTPEK VSEILARFNA
GTTGMGLIDA SQRELIHTGY TSNRTRQNVA SFLAKHLEID WRYGAEWYEM LLVDYDVSSN
WANWQYVAGV GNDPRGAARI FNPVKQAFDY DKDGTYVRTW VPEVAKFENL ENVFQAWTAS
KEDLKTAGLE GNIMVTDPVK PIKFNLDHKP SKVKKRPFFR KRGTKTRDAQ GSAESPGSSD
SHSGSGGSPD GSGGGNIPSE SNCAAAGSGQ AQQTHQGSGR SQSSSNHGGR SHSHQHNQQN
YHHSHRGNDY TRGGGGGRGG RGGRGGGGGG YSASQGYYGI GGGYRGGGRG RGGGGGFRGR
YAPTGGLGGH HHSEQQVASQ FQTDA
