ID   CRYD_RHOBA              Reviewed;         488 AA.
AC   Q7UJB1;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 2.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Cryptochrome DASH;
GN   Name=cry; Synonyms=phr; OrderedLocusNames=RB12007;
OS   Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1).
OC   Bacteria; Planctomycetes; Planctomycetia; Pirellulales; Pirellulaceae;
OC   Rhodopirellula.
OX   NCBI_TaxID=243090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10527 / NCIMB 13988 / SH1;
RX   PubMed=12835416; DOI=10.1073/pnas.1431443100;
RA   Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W.,
RA   Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R.,
RA   Reinhardt R.;
RT   "Complete genome sequence of the marine planctomycete Pirellula sp. strain
RT   1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003).
CC   -!- FUNCTION: May have a photoreceptor function. Binds DNA; probably
CC       functions as a transcriptional repressor (By similarity).
CC       {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC       Note=Binds 1 FAD per subunit. {ECO:0000250};
CC   -!- COFACTOR:
CC       Name=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate;
CC         Xref=ChEBI:CHEBI:15636; Evidence={ECO:0000250};
CC       Note=Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.
CC       {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the DNA photolyase class-1 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAD77347.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BX294154; CAD77347.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_870272.1; NC_005027.1.
DR   AlphaFoldDB; Q7UJB1; -.
DR   SMR; Q7UJB1; -.
DR   STRING; 243090.RB12007; -.
DR   EnsemblBacteria; CAD77347; CAD77347; RB12007.
DR   KEGG; rba:RB12007; -.
DR   PATRIC; fig|243090.15.peg.5804; -.
DR   eggNOG; COG0415; Bacteria.
DR   HOGENOM; CLU_010348_6_2_0; -.
DR   InParanoid; Q7UJB1; -.
DR   OrthoDB; 184000at2; -.
DR   Proteomes; UP000001025; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0003913; F:DNA photolyase activity; IEA:InterPro.
DR   GO; GO:0071949; F:FAD binding; IBA:GO_Central.
DR   GO; GO:0000719; P:photoreactive repair; IBA:GO_Central.
DR   Gene3D; 3.40.50.620; -; 1.
DR   InterPro; IPR014133; Cry_DASH.
DR   InterPro; IPR036134; Crypto/Photolyase_FAD-like_sf.
DR   InterPro; IPR036155; Crypto/Photolyase_N_sf.
DR   InterPro; IPR005101; Cryptochr/Photolyase_FAD-bd.
DR   InterPro; IPR002081; Cryptochrome/DNA_photolyase_1.
DR   InterPro; IPR018394; DNA_photolyase_1_CS_C.
DR   InterPro; IPR006050; DNA_photolyase_N.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR11455; PTHR11455; 1.
DR   Pfam; PF00875; DNA_photolyase; 1.
DR   Pfam; PF03441; FAD_binding_7; 1.
DR   PRINTS; PR00147; DNAPHOTLYASE.
DR   SUPFAM; SSF48173; SSF48173; 1.
DR   SUPFAM; SSF52425; SSF52425; 1.
DR   TIGRFAMs; TIGR02765; crypto_DASH; 1.
DR   PROSITE; PS00394; DNA_PHOTOLYASES_1_1; 1.
DR   PROSITE; PS51645; PHR_CRY_ALPHA_BETA; 1.
PE   3: Inferred from homology;
KW   Chromophore; DNA-binding; FAD; Flavoprotein; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..488
FT                   /note="Cryptochrome DASH"
FT                   /id="PRO_0000235310"
FT   DOMAIN          2..135
FT                   /note="Photolyase/cryptochrome alpha/beta"
SQ   SEQUENCE   488 AA;  56693 MW;  AFA221B6CF72C642 CRC64;
     MANALVWFRN DLRTIDHEPF LRASTADRCF AVHCIDPRQF ETTELGFQRT GPFRARFLIE
     NLTDLRSRLR SLGGELIVRV GRPETVLQHL LPSLAIDAVH FHHEPRTEEA DTAESVQQLC
     DQHGIATHVA YGDTLIHPDE LPFEIADTPE LFTDFRKEIE KQCEARSPLE EPIRIHGTLP
     EEVNAGDIPT LESLGLSTPP LDDRCLNQFT GGQNAAQQRM EEYIWNEDRL RVYKETRNGM
     LHPNDSSKFS PWLAQGCLSP RMIADHVRRY EEERVKNKST YWMIFELLWR DYFRWISRKH
     GATLFRAGGL RGVNVDWKSD RELFRRWQDG TTGYPLVDAN MRELRTTGYM SNRGRQNVAS
     FLTKNLGIDW RWGARWFESQ LVDYDVASNY GNWNYAAGVG NDARGFRFFN ITKQSRDYDS
     QGEYAKHWLP ELRDLDVTEI HEPWKMSPER QQEVGATLGK EYPHPIVDLF DSAKENETIY
     MRAKAASH