ID   CRYD_XENLA              Reviewed;         523 AA.
AC   Q75WS4;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Cryptochrome DASH;
GN   Name=cry-dash;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX   PubMed=15147276; DOI=10.1111/j.1356-9597.2004.00738.x;
RA   Daiyasu H., Ishikawa T., Kuma K., Iwai S., Todo T., Toh H.;
RT   "Identification of cryptochrome DASH from vertebrates.";
RL   Genes Cells 9:479-495(2004).
CC   -!- FUNCTION: May have a photoreceptor function (By similarity). Has weak
CC       cyclobutyl pyrimidine photolyase activity when expressed in E.coli and
CC       when tested in vitro. {ECO:0000250, ECO:0000269|PubMed:15147276}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC       Note=Binds 1 FAD per subunit. {ECO:0000250};
CC   -!- COFACTOR:
CC       Name=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate;
CC         Xref=ChEBI:CHEBI:15636; Evidence={ECO:0000250};
CC       Note=Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.
CC       {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the DNA photolyase class-1 family.
CC       {ECO:0000305}.
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DR   EMBL; AB120760; BAD08601.1; -; mRNA.
DR   RefSeq; NP_001084438.1; NM_001090969.1.
DR   AlphaFoldDB; Q75WS4; -.
DR   SMR; Q75WS4; -.
DR   MaxQB; Q75WS4; -.
DR   PRIDE; Q75WS4; -.
DR   GeneID; 403387; -.
DR   KEGG; xla:403387; -.
DR   CTD; 403387; -.
DR   Xenbase; XB-GENE-5887331; cry-dash.L.
DR   OrthoDB; 378952at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 403387; Expressed in ovary and 19 other tissues.
DR   GO; GO:0003913; F:DNA photolyase activity; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   Gene3D; 3.40.50.620; -; 1.
DR   InterPro; IPR014133; Cry_DASH.
DR   InterPro; IPR036134; Crypto/Photolyase_FAD-like_sf.
DR   InterPro; IPR036155; Crypto/Photolyase_N_sf.
DR   InterPro; IPR005101; Cryptochr/Photolyase_FAD-bd.
DR   InterPro; IPR002081; Cryptochrome/DNA_photolyase_1.
DR   InterPro; IPR006050; DNA_photolyase_N.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR11455; PTHR11455; 1.
DR   Pfam; PF00875; DNA_photolyase; 1.
DR   Pfam; PF03441; FAD_binding_7; 1.
DR   PRINTS; PR00147; DNAPHOTLYASE.
DR   SUPFAM; SSF48173; SSF48173; 1.
DR   SUPFAM; SSF52425; SSF52425; 1.
DR   TIGRFAMs; TIGR02765; crypto_DASH; 1.
DR   PROSITE; PS51645; PHR_CRY_ALPHA_BETA; 1.
PE   2: Evidence at transcript level;
KW   Chromophore; FAD; Flavoprotein; Reference proteome.
FT   CHAIN           1..523
FT                   /note="Cryptochrome DASH"
FT                   /id="PRO_0000235317"
FT   DOMAIN          6..142
FT                   /note="Photolyase/cryptochrome alpha/beta"
FT   REGION          174..211
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          486..523
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        507..523
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   523 AA;  60645 MW;  D5F62DDE3CEF19C1 CRC64;
     MCVPSRVIIC LLRNDLRLHD NEVLHWAHRN ADQIVPLYCF DPRHYVGTHY FNFPKTGPHR
     LKFLLESVRD LRITLKKKGS NLLLRRGKPE EVIEDLVKQL GNVSAVTLHE EATKEETDVE
     SAVKQACTRL GIKYQTFWGS TLYHREDLPF RHISSLPDVY TQFRKAVETQ GKVRPTFQMP
     DKLKPLPSGL EEGSVPSHED FDQQDPLTDP RTAFPCSGGE SQALQRLEHY FWETNLVASY
     KDTRNGLIGL DYSTKFAPWL ALGCVSPRYI YEQIGKYEKE RTANQSTYWV IFELLWRDYF
     RFVALKYGRR IFFLRGLQDK DIPWKRDPKL FDAWKEGRTG VPFVDANMRE LAMTGFMSNR
     GRQNVASFLT KDLGIDWRMG AEWFEYLLVD YDVCSNYGNW LYSAGIGNDP RENRKFNMIK
     QGLDYDSGGD YIRLWVPELQ QIKGGDAHTP WALSNASLAH ANLSLGETYP YPIVMAPEWS
     RHINQKPAGS WEKSARRGKG PSHTPKQHKN RGIDFYFSRN KDV