CRYGS_BOVIN
ID CRYGS_BOVIN Reviewed; 178 AA.
AC P06504;
DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Gamma-crystallin S;
DE AltName: Full=Beta-crystallin S;
DE AltName: Full=Gamma-S-crystallin;
GN Name=CRYGS;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=4054100; DOI=10.1002/j.1460-2075.1985.tb03976.x;
RA Quax-Jeuken Y., Driessen H.P.C., Leunissen J., Quax W.J., de Jong W.W.,
RA Bloemendal H.;
RT "Beta s-crystallin: structure and evolution of a distinct member of the
RT beta gamma-superfamily.";
RL EMBO J. 4:2597-2602(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2476364; DOI=10.1016/0378-1119(89)90225-4;
RA van Rens G.L.M., Raats J.M.H., Driessen H.P.C., Oldenburg M., Wijnen J.T.,
RA Khan P.M., de Jong W.W., Bloemendal H.;
RT "Structure of the bovine eye lens gamma s-crystallin gene (formerly beta
RT s).";
RL Gene 78:225-233(1989).
RN [3]
RP X-RAY CRYSTALLOGRAPHY (2.56 ANGSTROMS) OF 93-178.
RX PubMed=9681865; DOI=10.1093/protein/11.5.337;
RA Basak A.K., Kroone R.C., Lubsen N.H., Naylor C.E., Jaenicke R.,
RA Slingsby C.;
RT "The C-terminal domains of gammaS-crystallin pair about a distorted twofold
RT axis.";
RL Protein Eng. 11:337-344(1998).
CC -!- FUNCTION: Crystallins are the dominant structural components of the
CC vertebrate eye lens.
CC -!- SUBUNIT: Monomer.
CC -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC Greek key motifs.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR EMBL; X03006; CAA26791.1; -; mRNA.
DR EMBL; M21095; AAA30477.1; -; Genomic_DNA.
DR EMBL; M21094; AAA30477.1; JOINED; Genomic_DNA.
DR PIR; A91017; CYBOS.
DR RefSeq; NP_776717.1; NM_174292.2.
DR PDB; 1A7H; X-ray; 2.56 A; A/B=94-178.
DR PDBsum; 1A7H; -.
DR AlphaFoldDB; P06504; -.
DR PCDDB; P06504; -.
DR SMR; P06504; -.
DR STRING; 9913.ENSBTAP00000004084; -.
DR PaxDb; P06504; -.
DR Ensembl; ENSBTAT00000004084; ENSBTAP00000004084; ENSBTAG00000003140.
DR GeneID; 281724; -.
DR KEGG; bta:281724; -.
DR CTD; 1427; -.
DR VEuPathDB; HostDB:ENSBTAG00000003140; -.
DR VGNC; VGNC:27743; CRYGS.
DR eggNOG; ENOG502QQAM; Eukaryota.
DR GeneTree; ENSGT00940000160342; -.
DR HOGENOM; CLU_081883_1_1_1; -.
DR InParanoid; P06504; -.
DR OMA; PVEWGAV; -.
DR OrthoDB; 1225331at2759; -.
DR EvolutionaryTrace; P06504; -.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000003140; Expressed in pigment epithelium of eye and 87 other tissues.
DR GO; GO:0005212; F:structural constituent of eye lens; IBA:GO_Central.
DR GO; GO:0002088; P:lens development in camera-type eye; IBA:GO_Central.
DR GO; GO:0002009; P:morphogenesis of an epithelium; IEA:Ensembl.
DR GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR Pfam; PF00030; Crystall; 2.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 2.
DR SUPFAM; SSF49695; SSF49695; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Eye lens protein; Reference proteome; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT CHAIN 2..178
FT /note="Gamma-crystallin S"
FT /id="PRO_0000057564"
FT DOMAIN 6..44
FT /note="Beta/gamma crystallin 'Greek key' 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 45..87
FT /note="Beta/gamma crystallin 'Greek key' 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 94..134
FT /note="Beta/gamma crystallin 'Greek key' 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT DOMAIN 135..177
FT /note="Beta/gamma crystallin 'Greek key' 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT REGION 2..5
FT /note="N-terminal arm"
FT REGION 88..93
FT /note="Connecting peptide"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:P22914, ECO:0000305"
FT STRAND 95..101
FT /evidence="ECO:0007829|PDB:1A7H"
FT HELIX 102..104
FT /evidence="ECO:0007829|PDB:1A7H"
FT STRAND 108..113
FT /evidence="ECO:0007829|PDB:1A7H"
FT HELIX 118..122
FT /evidence="ECO:0007829|PDB:1A7H"
FT STRAND 129..135
FT /evidence="ECO:0007829|PDB:1A7H"
FT STRAND 137..142
FT /evidence="ECO:0007829|PDB:1A7H"
FT TURN 143..145
FT /evidence="ECO:0007829|PDB:1A7H"
FT STRAND 146..152
FT /evidence="ECO:0007829|PDB:1A7H"
FT STRAND 154..159
FT /evidence="ECO:0007829|PDB:1A7H"
FT HELIX 160..163
FT /evidence="ECO:0007829|PDB:1A7H"
FT STRAND 172..175
FT /evidence="ECO:0007829|PDB:1A7H"
SQ SEQUENCE 178 AA; 20928 MW; 03953B5627186F1D CRC64;
MSKAGTKITF FEDKNFQGRH YDSDCDCADF HMYLSRCNSI RVEGGTWAVY ERPNFAGYMY
ILPRGEYPEY QHWMGLNDRL SSCRAVHLSS GGQYKLQIFE KGDFNGQMHE TTEDCPSIME
QFHMREVHSC KVLEGAWIFY ELPNYRGRQY LLDKKEYRKP VDWGAASPAV QSFRRIVE
